Education backgroud:                                                                                                              
2016.09-2020.06:  Bachelor,  pharmaceutical engineering，Shanghai Institute of Technology

2020.09- present:  MD-PhD,  Pharmacy,   East China University of Science and Technology.

Research Interests:                                                                                                                   

1.Lead discovery and optimization

2.De novo drug design & Molecular generation

3.Molecular dynamics simulation

Presentative Publications:                                                                                                       

1.Feng Hu, Xiaotong Jia, Wenjie Liao, Ziqi Chen, Hongjie Bi, Huan Ge, Dandan Liu,  
Rongrong Zhang, Yuting Hu, Wenyi Mei, Zhenjiang Zhao, Kai Zhang*, Lili Zhu*, Yanyan  
Diao*, Honglin Li*. Exploring the macrocyclic chemical space for heuristic drug design  
with deep learning models. Communications Chemistry, 2025, 8: 299.

2.Yuting Hu† , Feng Hu†, Hongwen Zhang†, Hongling Xu, Jixiang Gao, Wenshuai Deng,  
Zijing Tian, Qiaoyu Hu, Honglin Li*, Yanyan Diao*. RPSubAlign: a novel sequence-based  
molecular representation method for retrosynthesis prediction with improved validity and  
robustness. Briefings in Bioinformatics, 2025, 26(3): bbaf257.

3.Wenyi Mei†, Xiaotong Jia †, Feng Hu†, Wenjie Liao, Ziqi Chen, Hongjie Bi, Zhenjiang  
Zhao, Zhuo Chen, Honglin Li*, Lili Zhu*, Yanyan Diao*. Design, Synthesis, and Biological  
Evaluation of Macrocyclic2 -Amino-4-phenylaminopyrimidine Derivatives as Potent JAK2  
Inhibitors. Journal of Medicinal Chemistry, 2025, 68, 13822-13835.

4.Yanyan Diao, Feng Hu, Zihao Shen, Honglin Li*. MacFrag: segmenting large-scale molecules to obtain diverse fragments with high qualities.MacFrag: segmenting large-scale molecules to obtain diverse fragments with high qualities. Bioinformatics,2023. 39(1) : btad012.

5.ZiJing. Tian†, Yan Dai†, Feng Hu, ZiHao Shen, HongLing Xu, HongWen Zhang, JinHang  
Xu, YuTing Hu, YanYan Diao*, and Honglin Li*. Enhancing Chemical Reaction  
Monitoring with a Deep Learning Model for NMR Spectra Image Matching to Target  
Compounds. Journal of Chemical Information and Modeling, 2024, 64: 5624-5633.

6.李洪林，朱丽丽，刁妍妍，胡枫，李鑫鑫；中国专利，抑制 SIRPα 与 CD47 结合的 
系列环肽及其应用，2025.12.19，申请号 202511929829.4

7.Junqing Liang, Jie Han, JinJin Wu*, PingJie Wu, Jian Hu, Feng Hu, FanHong Wu*. Nickel-Catalyzed Coupling Reaction of α-Bromo-α-fluoroketones with Arylboronic Acids toward the Synthesis of α-Fluoroketones. Org. Lett. 2019, 21(17): 6844–6849.