Zhenjiang Zhao

Education & Work Experience                                                                    

  • 1986.9 ~ 1990.2     Master,  Northwest University;
  • 1990.2 ~ 2001.7     worked in China Lucky Film Co.;
  • 2001.9 ~ 2004.7    Ph.D. at East China University of Science and Technology; 
  • 2005.9 ~ 2008.7     Post Doctor, Shanghai Jiaotong University;
  • 2004.8 ~ 2010.4     worked in Zannan Pharmaceutical Co.;
  • 2010.5 ~ Present   Shanghai Key Laboratory of New Drug Design of ECUST;

Research Interests                                                                                       
 

1. Medicinal chemistry, mainly on some enzymes inhibitors R&D.

2. Plant protection, plant activators R&D.

3. Structural optimization and organic synthesis.
 

Publications

  1.  Mengzhu Xue, Jun Yuan, Bin Wu, Xue Zhao, Xiaofeng Liu, Jin Huang, Zhenjiang Zhao, Honglin Li, Yufang Xu. Novel inhibitors for p90 ribosomal S6 protein kinase 2: design, synthesis and SAR. Journal of Chinese Pharmaceutical Sciences 21 (2012) 401–402 1–408.
  2.  2. Yanyan Diao,† Weiqiang Lu,† Huangtao Jin, Junsheng Zhu, Le Han, Minghao Xu, Rui Gao, Xu Shen, Zhenjiang Zhao, Xiaofeng Liu, Yufang Xu, Jin Huang,* and Honglin Li*. Discovery of Diverse Human Dihydroorotate Dehydrogenase Inhibitors as mmunosuppressive Agents by Structure-Based Virtual Screening. J. Med. Chem. 2012, 55, 8341−8349..
  3. Mengzhu Xue, Xianwen Cao, Ye Zhong, Dong Kuang, Xiaofeng Liu, Zhenjiang Zhao and Honglin Li*. Insulin-like Growth Factor-1 Receptor (IGF-1R) Kinase Inhibitors in Cancer Therapy: Advances and Perspectives. Current Pharmaceutical Design, 2012, 18, 2901-2913
  4. Mengzhu Xue, Minghao Xu, Weiqiang Lu, Jin Huang, Honglin Li, Yufang Xu, Xiaofeng Liu, and Zhenjiang Zhao. Synthesis, activity evaluation, and docking analysis of barbituric acid aryl hydrazone derivatives as RSK2 inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry, 2012; Early Online: 1–6
  5. Qingshan Du, Weiping Zhu, Zhenjiang Zhao, Xuhong Qian, and Yufang Xu. Novel Benzo-1,2,3-thiadiazole-7-carboxylate Derivatives As Plant Activators and the Development of Their Agricultural Applications. J. Agric. Food Chem. 2012, 60, 346−353.
  6. Fang Bai, Hongyan Liu, Linjiang Tong, Wei Zhou, Li Liu, Zhenjiang Zhao, Xiaofeng Liu, Hualiang Jiang, Xicheng Wang, Hua Xie, Honglin Li. Discovery of novel selective inhibitors for EGFR-T790M/L858R. Bioorganic & Medicinal Chemistry Letters 22 (2012) 1365–1370.(1)
  7. Shiliang Li, Yi Zhou, Weiqiang Lu, Ye Zhong, Wenlong Song, Kangdong Liu, Jin Huang, Zhenjiang Zhao, Yufang Xu, Xiaofeng Liu, and Honglin Li. Identification of Inhibitors against p90 Ribosomal S6 Kinase 2 (RSK2) through Structure-Based Virtual Screening with the Inhibitor-Constrained Refined Homology Model. J. Chem. Inf. Model. 2011, 51, 2939–2947.
  8. Huameng Li, Aiguo Liu, Zhenjiang Zhao, Yufang Xu, Jiayuh Lin, David Jou, and Chenglong Li. Fragment-Based Drug Design and Drug Repositioning Using Multiple Ligand simultaneous Docking (MLSD): Identifying Celecoxib and Template Compounds as Novel Inhibitors of Signal Transducer and Activator of Transcription 3 (STAT3). J. Med. Chem. 2011, 54, 5592–5596.
  9. Weiqiang Lu, Xiaofeng Liu, Xianwen Cao, Mengzhu Xue, Kangdong Liu, Zhenjiang Zhao, Xu Shen, Hualiang Jiang, Yufang Xu, Jin Huang, and Honglin Li. SHAFTS: A Hybrid Approach for 3D Molecular Similarity Calculation. 2. Prospective Case Study in the Discovery of Diverse p90 Ribosomal S6 Protein Kinase 2 Inhibitors To Suppress Cell Migration. J. Med. Chem. 2011, 54, 3564–3574.
  10. Weiping Zhu, Zhenjiang Zhao, Yufang Xu,* Derivatives of Benzothiadiazole-7- Carboxylates: Synthesis and Biological Activityï¼ÂÂÂŒMonatshefte fur Chemieï¼ÂÂÂŒ2008ï¼ÂÂÂŒ39ï¼ÂÂÂŒ1067-1071
  11. Zhenjiang Zhao, Z-Y. James Zhan, Development of new ruthenium catalysts for metathesis reactions, Chemistry Today, Vol 24 nr 6, 2006
  12. Qian Zhigang, Zhao Zhenjiang, etc. Novel Chemically Synthesized Salicylate Derivative as an Effective Elicitor for Inducing the Biosynthesis of Plant Secondary Metabolites, Biotechnol. Prog. 2006, 22, 331-333
  13. Yufang Xu, Zhenjiang Zhao, Xuhong Qian, Zhigang Qian, Wenhong Tian, Jian-Jiang Zhong, Novel Unnatural Benzo-1,2,3-thiadiazole-7-carboxylate Elicitors of Taxoid Biosynthesis  Journal of Agricultural Food Chemistry 54 (23): 8793-8798 2006
  14. Zhi-Gang Qian, Zhen-Jiang Zhao, Yufang Xu, Xuhong Qian and Jian-Jiang Zhong Novel synthetic 2,6-dichloroisonicotinate derivatives as effective elicitors for inducing the biosynthesis of plant secondary metabolites Applied Microbiology and Biotechnology, 71 (2): 164-167 2006
  15. Wei wang, Zhenjiang Zhao, Yufang Xu, Xuhong Qian, Zhanjiang Zhong, Efficient Induction of Ginsenoside Biosynthesis and Alteration of Ginsenoside Heterogeneity in Cell Cultures of Panax notoginseng by Using Chemically Synthesized 2-Hydroxyethyl Jasmonate, Applied Microbiology & Biotechnology, 70 (3): 298-307 2006
  16. Wei Wang, Zhenjiang Zhao, etc. Efficient elicatation of Ginsenoside biosynthesis in cell cultures of panax notoginseng by using self-chemically-synthesized Jasmonates, Biotechnology and Bioprocess Engineering 2005, 10: 162-165
  17. Zhi-Gang Qian, Zhen-Jiang Zhao ,Yufang Xu , Xuhong Qian , Jian-Jiang Zhong, A novel synthetic fluoro-containing jasmonate derivative acts as a chemical inducing signal for plant secondary metabolism, Applied Microbiology and Biotechnology, 2005,68,98-103
  18. Zhi-Gang Qian, Zhen-Jiang Zhao, Yufang Xu, Xuhong Qian, Jian-Jiang Zhong, A Highly Efficient Strategy for Enhancing Taxoid Production by Repeated Elicitation with a Newly Synthesized Jasmonate in Fed-batch Cultivation of Taxus chinensis Cells, Biotechnology and Bioengineering 90 (4): 516-521 2005
  19. Zhi-Gang Qian, Zhen-Jiang Zhao, Wen-Hong Tian, Yufang Xu, Jian-Jiang Zhong, Xuhong Qian, Novel Synthetic Jasmonates as Highly Efficient Elicitors for Taxoid Production by Suspension Cultures of Taxus chinensis, Biotechnology Bioengineering.86(5), 2004, 594- 599.
  20. Zhi-Gang Qian, Zhen-Jiang Zhao, Yufang Xu, Xuhong Qian, Jian-Jiang Zhong, Novel Chemically Synthesized Hydroxyl-Containing Jasmonates as Powerful Inducing Signals for Plant Secondary Metabolism Biotechnology Bioengineering  86(7), 2004,809-816.
  21. Zhenjiang Zhao, Yufang Xu, Zhigang Qian, Wenhong Tian, Xuhong Qian, Jian-Jiang Zhong Novel fluoro- and hydroxyl-containing jasmonate derivatives as highly efficient elicitors in suspension cultures of Taxus chinensis Bioorganic and medicinal chemistry Letter, 14(18),2004, 4755-4758
  22. Zhenjiang Zhao, Horst Hartmann. Synthesis of reactive condensation products of acetylaceton and their transformation into deeply colored metthine dyes. J. Prakt. Chem. 2000, 342(3), 249-255.

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Honglin Li's Lab
Shanghai Key Laboratory of New Drug Design
School of Pharmacy
East China University of Sci. & Tech.
Room 527, Building 18, 130 Meilong Road,
Shanghai, 200237, P. R. China
Tel: (86) 21 6425 0213
Prof. Honglin Li
hlli@ecust.edu.cn

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