iDNABinder

iDNABinder is an in-house specific molecular docking tool for DNA-ligand docking, whose scoring function comprises DNA-specific knowledge-based and force field-based scoring functions. It could be used to screen for small molecular docking or virtual screening against the specific DNA sequence and has been successfully applied to identifying potent natural modulator of AP-1, which selectively binds to a specific site (TRE 5`-TGACTCA-3`) of the AP-1 target DNA sequence and regulates AP-1-dependent gene transcription.

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Honglin Li's Lab
Shanghai Key Laboratory of New Drug Design
School of Pharmacy
East China University of Sci. & Tech.
Room 527, Building 18, 130 Meilong Road,
Shanghai, 200237, P. R. China
Tel: (86) 21 6425 0213
Prof. Honglin Li
hlli@ecust.edu.cn

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