| Name | BIN2 |
|---|---|
| Synonyms | BIN 2; BIN2; BRAP 1; BRAP1; Breast cancer associated protein 1; Bridging integrator 2; Breast cancer associated protein 1s; Bridging integrator 2s |
| Name | brassinolide |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12428015 | Choe S, Schmitz RJ, Fujioka S, Takatsuto S, Lee MO, Yoshida S, Feldmann KA, Tax FE: Arabidopsis brassinosteroid-insensitive dwarf12 mutants are semidominant and defective in a glycogen synthase kinase 3beta-like kinase. Plant Physiol. 2002 Nov;130(3):1506-15. Together with previous reports that both bin2 and ucu1 mutants contain mutations in this TREE domain, this provides evidence that the TREE domain is of critical importance for proper function of DWF12/BIN2/UCU1 in BR signal transduction pathways. Like bri1 mutants, dwf12 plants accumulated castasterone and brassinolide, 43- and 15-fold higher, respectively, providing further evidence that DWF12 is a component of the BR signaling pathway that includes BRI1. |
1(0,0,0,1) | Details |
| 17003466 | Karlova R, de Vries SC: Advances in understanding brassinosteroid signaling. Sci STKE. 2006 Sep 26;2006(354):pe36. In the presence of BR, the kinase BIN2, which is the Arabidopsis homolog of GSK3 (glycogen synthase kinase 3), is inhibited by an unknown mechanism, leading to dephosphorylation of BES1 and BZR1 inside the nucleus. |
1(0,0,0,1) | Details |
| 14977918 | Mora-Garcia S, Vert G, Yin Y, Cano-Delgado A, Cheong H, Chory J: Nuclear protein phosphatases with Kelch-repeat domains modulate the response to brassinosteroids in Arabidopsis. Genes Dev. 2004 Feb 15;18(4):448-60. Epub 2004 Feb 20. Perception of the plant steroid hormone brassinolide (BL) by the membrane-associated receptor kinase BRI1 triggers the dephosphorylation and accumulation in the nucleus of the transcriptional modulators BES1 and BZR1. BSU1 is able to modulate the phosphorylation state of BES1, counter acting the action of the glycogen synthase kinase-3 BIN2, and leading to inc eased steady-state levels of dephosphorylated BES1. |
1(0,0,0,1) | Details |
| 12427989 | Zhao J, Peng P, Schmitz RJ, Decker AD, Tax FE, Li J: Two putative BIN2 substrates are nuclear components of brassinosteroid signaling. Plant Physiol. 2002 Nov;130(3):1221-9. |
7(0,0,0,7) | Details |
| 19395409 | Yan Z, Zhao J, Peng P, Chihara RK, Li J: BIN2 functions redundantly with other Arabidopsis GSK3-like kinases to regulate brassinosteroid signaling. Plant Physiol. 2009 Jun;150(2):710-21. Epub 2009 Apr 24. |
6(0,0,0,6) | Details |
| 11553730 | Li J, Nam KH, Vafeados D, Chory J: BIN2, a new brassinosteroid-insensitive locus in Arabidopsis. Plant Physiol. 2001 Sep;127(1):14-22. |
4(0,0,0,4) | Details |
| 19734888 | Kim TW, Guan S, Sun Y, Deng Z, Tang W, Shang JX, Sun Y, Burlingame AL, Wang ZY: Brassinosteroid signal transduction from cell-surface receptor kinases to nuclear transcription factors. Nat Cell Biol. 2009 Oct;11(10):1254-60. Epub 2009 Sep 6. We show that phosphorylation of BSK1 (BR-signalling kinase 1) by the BR receptor kinase BRI1 (BR-insensitive 1) promotes BSK1 binding to the BSU1 (BRI1 suppressor 1) phosphatase, and BSU1 inactivates the GSK3-like kinase BIN2 (BR-insensitive 2) by dephosphorylating a conserved phospho- residue (pTyr 200). |
3(0,0,0,3) | Details |
| 16699538 | Wang ZY, Wang Q, Chong K, Wang F, Wang L, Bai M, Jia C: The brassinosteroid signal transduction pathway. Cell Res. 2006 May;16(5):427-34. Activated BRI1 or BAK1 then regulate, possibly indirectly, the activities of BIN2 kinase and/or BSU1 phosphatase, which directly regulate the phosphorylation status and nuclear accumulation of two homologous transcription factors, BZR1 and BES1. |
1(0,0,0,1) | Details |
| 19549598 | De Rybel B, Audenaert D, Vert G, Rozhon W, Mayerhofer J, Peelman F, Coutuer S, Denayer T, Jansen L, Nguyen L, Vanhoutte I, Beemster GT, Vleminckx K, Jonak C, Chory J, Inze D, Russinova E, Beeckman T: Chemical inhibition of a subset of Arabidopsis thaliana GSK3-like kinases activates brassinosteroid signaling. Chem Biol. 2009 Jun 26;16(6):594-604. Bikinin directly binds the GSK3 BIN2 and acts as an ATP competitor. |
1(0,0,0,1) | Details |
| 15973517 | Sun Y, Allen RD: Functional analysis of the BIN 2 genes of cotton. Mol Genet Genomics. 2005 Aug;274(1):51-9. Epub 2005 Jun 23. Transgenic Arabidopsis plants that express these cotton BIN 2 cDNAs show reduced growth and similar phenotypes to the semi-dominant bin 2 mutant plants. |
1(0,0,0,1) | Details |