Protein Information

Name transmembrane receptor
Synonyms CD304; NRP; NRP 1; NRP1; CD304 antigen; Neuropilin 1; Neuropilin 1 precursor; RP11 342D11.1…

Compound Information

Name brassinolide
CAS

Reference List

PubMed Abstract RScore(About this table)
19532123 Song L, Shi QM, Yang XH, Xu ZH, Xue HW: Membrane steroid-binding protein 1 (MSBP1) negatively regulates brassinosteroid signaling by enhancing the endocytosis of BAK1. Cell Res. 2009 Jul;19(7):864-76.

The transmembrane receptor BRI1 can directly bind to brassinolide (BL), and BAK1 interacts with BRI1 to enhance the BRI1-mediated BR signaling.
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18694562 Wang X, Kota U, He K, Blackburn K, Li J, Goshe MB, Huber SC, Clouse SD: Sequential transphosphorylation of the BRI1/BAK1 receptor kinase complex impacts early events in brassinosteroid signaling. Dev Cell. 2008 Aug;15(2):220-35.


Brassinosteroids (BRs) regulate plant development through a signal transduction pathway involving the BRI1 and BAK1 transmembrane receptor kinases.
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20103591 Schulze B, Mentzel T, Jehle AK, Mueller K, Beeler S, Boller T, Felix G, Chinchilla D: Rapid heteromerization and phosphorylation of ligand-activated plant transmembrane receptors and their associated kinase BAK1. J Biol Chem. 2010 Mar 26;285(13):9444-51. Epub 2010 Jan 26.

Similarly, brassinolide induces BAK1 phosphorylation within seconds.
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17003466 Karlova R, de Vries SC: Advances in understanding brassinosteroid signaling. Sci STKE. 2006 Sep 26;2006(354):pe36.


Unlike animal steroids that are perceived by nuclear receptors, BRs are perceived by transmembrane receptor kinase complexes that initiate a phosphorylation-mediated signaling cascade to transduce the steroid signal.
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11268216 Wang ZY, Seto H, Fujioka S, Yoshida S, Chory J: BRI1 is a critical component of a plasma-membrane receptor for plant steroids. Nature. 2001 Mar 15;410(6826):380-3.

However, a transmembrane receptor kinase, brassinosteroid-insensitive1 (BRI1), has been implicated in brassinosteroid responses.
Here we show that BRI1 functions as a receptor of brassinolide, the most active brassinosteroid.
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12972051 Li J: Brassinosteroids signal through two receptor-like kinases. Curr Opin Plant Biol. 2003 Oct;6(5):494-9.


Animal steroids are mainly recognized by intracellular steroid receptors, whereas plant steroids are perceived by cell-surface receptors that contain a transmembrane receptor serine/threonine kinase.
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11746219 Friedrichsen D, Chory J: Steroid signaling in plants: from the cell surface to the nucleus. . Bioessays. 2001 Nov;23(11):1028-36.


Molecular genetic studies in Arabidopsis thaliana have led to the cloning and characterization of the BR receptor, BRI1, which is a transmembrane receptor serine/threonine kinase.
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