| Name | NADH:ubiquinone oxidoreductase (protein family or complex) |
|---|---|
| Synonyms | NADH ubiquinone oxidoreductase; NADH ubiquinone oxidoreductases; NADH:ubiquinone oxidoreductase; NADH:ubiquinone oxidoreductases |
| Name | pyridaben |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11695186 | Schuler F, Casida JE: The insecticide target in the PSST subunit of complex I. . Pest Manag Sci. 2001 Oct;57(10):932-40. This process has often ended up with compounds of high potency as inhibitors of the electron transport chain and more specifically of complex I (NADH:ubiquinone oxidoreductase). We used a potent photoaffinity ligand, (trifluoromethyl) diazirinyl [3H] pyridaben, to localize the insecticide target to a single high-affinity site in the PSST subunit that couples electron transfer from iron- cluster N2 to |
1(0,0,0,1) | Details |
| 9520374 | Fang N, Casida JE: Anticancer action of cube insecticide: correlation for rotenoid constituents between inhibition of NADH:ubiquinone oxidoreductase and induced ornithine decarboxylase activities. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3380-4. These findings on cube insecticide constituents and our earlier study comparing rotenone and pyridaben miticide indicate that inhibition of NADH:ubiquinone oxidoreductase activity lowers the level of induced ODC activity leading to the antiproliferative effect and anticancer action. |
85(1,1,1,5) | Details |
| 11245783 | Prieur I, Lunardi J, Dupuis A: Evidence for a binding site close to the interface between NUOD and NUOB subunits of Complex I. Biochim Biophys Acta. 2001 Apr 2;1504(2-3):173-8. Piericidin, rotenone and pyridaben are specific inhibitors of the NADH-ubiquinone oxidoreductase (Complex I) that bind to its binding site (s). |
81(1,1,1,1) | Details |
| 11418099 | Schuler F, Casida JE: Functional coupling of PSST and ND1 subunits in NADH:ubiquinone oxidoreductase established by photoaffinity labeling. Biochim Biophys Acta. 2001 Jul 2;1506(1):79-87. Photoaffinity labeling with the highly potent and specific inhibitor trifluoromethyldiazirinyl-[(3) H] pyridaben ([(3) H] TDP) labels only the PSST and ND1 subunits of complex I in electron transport particles. |
2(0,0,0,2) | Details |
| 12231169 | Seo BB, Nakamaru-Ogiso E, Flotte TR, Yagi T, Matsuno-Yagi A: A single-subunit -quinone oxidoreductase renders resistance to mammalian nerve cells against complex I inhibition. Mol Ther. 2002 Sep;6(3):336-41. Numerous studies suggest that dysfunction of mitochondrial -translocating NADH-ubiquinone oxidoreductase (complex I) is associated with neurodegenerative disorders, such as Parkinson's disease and Huntington's disease. The cells expressing the Ndi1 protein were resistant to known inhibitors of complex I, such as rotenone and pyridaben. |
1(0,0,0,1) | Details |