| Name | complex I |
|---|---|
| Synonyms | 39kD; CI 39kD; Complex I; Complex I 39kD; NADH dehydrogenase (ubiquinone) Fe S protein 2 like; NADH ubiquinone oxidoreductase 39 kDa subunit mitochondrial; NADH ubiquinone oxidoreductase 39 kDa subunit; NDUFA 9… |
| Name | pyridaben |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19168698 | Ratner V, Starkov A, Matsiukevich D, Polin RA, Ten VS: Mitochondrial dysfunction contributes to alveolar developmental arrest in hyperoxia-exposed mice. Am J Respir Cell Mol Biol. 2009 May;40(5):511-8. Epub 2009 Jan 23. A separate cohort of mice was exposed to pyridaben, a complex-I (C-I) inhibitor, for 72 hours or 2 weeks. |
81(1,1,1,1) | Details |
| 20056551 | Mou T, Jing H, Yang W, Fang W, Peng C, Guo F, Zhang X, Pang Y, Ma Y: Preparation and biodistribution of [18F] FP2OP as myocardial perfusion imaging agent for positron emission tomography. Bioorg Med Chem. 2010 Feb;18(3):1312-20. Epub 2009 Dec 26. Myocardial extractions of pyridaben, a mitochondrial complex I (MC-I) inhibitor, is well correlated with blood flow. |
81(1,1,1,1) | Details |
| 12231169 | Seo BB, Nakamaru-Ogiso E, Flotte TR, Yagi T, Matsuno-Yagi A: A single-subunit -quinone oxidoreductase renders resistance to mammalian nerve cells against complex I inhibition. Mol Ther. 2002 Sep;6(3):336-41. The cells expressing the Ndi1 protein were resistant to known inhibitors of complex I, such as rotenone and pyridaben. |
36(0,1,1,6) | Details |
| 11418099 | Schuler F, Casida JE: Functional coupling of PSST and ND1 subunits in NADH:ubiquinone oxidoreductase established by photoaffinity labeling. Biochim Biophys Acta. 2001 Jul 2;1506(1):79-87. Photoaffinity labeling with the highly potent and specific inhibitor trifluoromethyldiazirinyl-[(3) H] pyridaben ([(3) H] TDP) labels only the PSST and ND1 subunits of complex I in electron transport particles. |
35(0,1,1,5) | Details |
| 10097178 | Schuler F, Yano T, Di Bernardo S, Yagi T, Yankovskaya V, Singer TP, Casida JE: -quinone oxidoreductase: PSST subunit couples electron transfer from iron- cluster N2 to Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):4149-53. Complex I and NDH-1 are very sensitive to inhibition by a variety of structurally diverse toxicants, including rotenone, piericidin A, bullatacin, and pyridaben. |
33(0,1,1,3) | Details |
| 18022104 | Yalamanchili P, Wexler E, Hayes M, Yu M, Bozek J, Kagan M, Radeke HS, Azure M, Purohit A, Casebier DS, Robinson SP: Mechanism of uptake and retention of F-18 BMS-747158-02 in cardiomyocytes: a novel PET myocardial imaging agent. J Nucl Cardiol. 2007 Nov-Dec;14(6):782-8. Epub 2007 Oct 22. METHODS AND RESULTS: 19 BMS-747158-01 inhibited mitochondrial complex I (MC-I) in bovine heart submitochondrial particles with an IC (50) of 16.6 +/- 3 nmol/L that was comparable to the reference inhibitors of MC-1, rotenone, pyridaben, and deguelin (IC (50) of 18.2 +/- 6.7 nmol/L, 19.8 +/- 2.6 nmol/L, and 23.1 +/- 1.5 nmol/L, respectively). |
31(0,1,1,1) | Details |
| 16239214 | Ved R, Saha S, Westlund B, Perier C, Burnam L, Sluder A, Hoener M, Rodrigues CM, Alfonso A, Steer C, Liu L, Przedborski S, Wolozin B: Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans. J Biol Chem. 2005 Dec 30;280(52):42655-68. Epub 2005 Oct 19. C. elegans lines with these genetic changes were more vulnerable than nontransgenic nematodes to mitochondrial complex I inhibitors, including rotenone, fenperoximate, pyridaben, or stigmatellin. |
31(0,1,1,1) | Details |
| 17241123 | Sherer TB, Richardson JR, Testa CM, Seo BB, Panov AV, Yagi T, Matsuno-Yagi A, Miller GW, Greenamyre JT: Mechanism of toxicity of pesticides acting at complex I: relevance to environmental etiologies of Parkinson's disease. J Neurochem. 2007 Mar;100(6):1469-79. Epub 2007 Jan 4. The rank order of toxicity of pesticides to neuroblastoma cells was pyridaben > rotenone > fenpyroximate > fenazaquin > tebunfenpyrad. |
7(0,0,0,7) | Details |
| 11695186 | Schuler F, Casida JE: The insecticide target in the PSST subunit of complex I. . Pest Manag Sci. 2001 Oct;57(10):932-40. We used a potent photoaffinity ligand, (trifluoromethyl) diazirinyl [3H] pyridaben, to localize the insecticide target to a single high-affinity site in the PSST subunit that couples electron transfer from iron- cluster N2 to |
3(0,0,0,3) | Details |
| 14699012 | Cherednichenko G, Zima AV, Feng W, Schaefer S, Blatter LA, Pessah IN: oxidase activity of rat cardiac sarcoplasmic reticulum regulates -induced release. Circ Res. 2004 Mar 5;94(4):478-86. Epub 2003 Dec 29. A significant contribution by mitochondria was excluded as oxidation by SR exhibited > 9-fold higher catalytic activity (8.8 micromol/mg protein per minute) in the absence of exogenous mitochondrial complex I or complex III (cytochrome c) electron acceptors, but was inhibited by rotenone and pyridaben (IC50=2 to 3 nmol/L), antimycin A (IC50=13 nmol/L), and diphenyleneiodonium (IC50=28 micromol/L). |
0(0,0,0,0) | Details |
| 17127363 | Gomez C, Bandez MJ, Navarro A: Pesticides and impairment of mitochondrial function in relation with the parkinsonian syndrome. Front Biosci. 2007 Jan 1;12:1079-93. The determination of -cytochrome c reductase, -cytochrome c reductase and cytochrome oxidase activities in rat brain submitochondrial showed again the selective inhibition of Complex I by rotenone and pyridaben, whereas paraquat produced a non-selective inhibition affecting all the respiratory chain complexes. |
113(1,2,2,3) | Details |
| 11245783 | Prieur I, Lunardi J, Dupuis A: Evidence for a binding site close to the interface between NUOD and NUOB subunits of Complex I. Biochim Biophys Acta. 2001 Apr 2;1504(2-3):173-8. Piericidin, rotenone and pyridaben are specific inhibitors of the NADH-ubiquinone oxidoreductase (Complex I) that bind to its binding site (s). |
83(1,1,1,3) | Details |