Protein Information

Name immunoglobulin (protein family or complex)
Synonyms Immunoglobulin; Immunoglobulins

Compound Information

Name valone
CAS

Reference List

PubMed Abstract RScore(About this table)
2971621 Sullam PM, Jarvis GA, Valone FH: Role of immunoglobulin G in platelet aggregation by viridans group streptococci. Infect Immun. 1988 Nov;56(11):2907-11.

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21340841 Kaufman PA, Wallace PK, Valone FH, Wells WA, Memoli VA, Ernstoff MS: Bispecific Antibody MDX-210 for Treatment of Advanced Ovarian and Breast Cancer. Methods Mol Med. 2001;39:793-806.


Additionally, although humanized MAbs are being developed, when used therapeutically their immunological effectiveness may be limited by high concentrations of nonspecific immunoglobulin (Ig) in patient serum.
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7545221 Valone FH, Kaufman PA, Guyre PM, Lewis LD, Memoli V, Deo Y, Graziano R, Fisher JL, Meyer L, Mrozek-Orlowski M, et al.: Phase Ia/Ib trial of bispecific antibody MDX-210 in patients with advanced breast or ovarian cancer that overexpresses the proto-oncogene HER-2/neu. J Clin Oncol. 1995 Sep;13(9):2281-92.


PURPOSE: MDX-210 is a bispecific antibody that binds simultaneously to type I Fc receptors for immunoglobulin G (IgG) (Fc gamma RI) and to the HER-2/neu oncogene protein product.
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