Protein Information

Name helicase
Synonyms CHLR 2; CHLR2; DDX12; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 12 (S.cerevisiae CHL1 like helicase); Helicase; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 12 (S.cerevisiae CHL1 like helicase)s; Helicases

Compound Information

Name sulfur
CAS sulfur

Reference List

PubMed Abstract RScore(About this table)
20137776 van der Lelij P, Chrzanowska KH, Godthelp BC, Rooimans MA, Oostra AB, Stumm M, Zdzienicka MZ, Joenje H, de Winter JP: Warsaw breakage syndrome, a cohesinopathy associated with mutations in the XPD helicase family member DDX11/ChlR1. Am J Hum Genet. 2010 Feb 12;86(2):262-6. Epub 2010 Feb 4.

The iron-sulfur-containing DNA helicases XPD, FANCJ, DDX11, and RTEL represent a small subclass of superfamily 2 helicases.
7(0,0,1,2) Details
19542287 Cromie GA: Phylogenetic ubiquity and shuffling of the bacterial RecBCD and AddAB recombination complexes. J Bacteriol. 2009 Aug;191(16):5076-84. Epub 2009 Jun 19.

RecBCD and AddAB are bacterial enzymes that share similar helicase and nuclease activities and initiate repair of DNA double-strand breaks by homologous recombination.
Finally, it appears that two sequence motifs, the Walker A box involved in ATP binding and an iron-sulfur-cysteine cluster, are present only in subsets of AddB proteins, suggesting the existence of mechanistically distinct classes of AddB.
1(0,0,0,1) Details
20167274 Pugh RA, Honda M, Spies M: Ensemble and single-molecule fluorescence-based assays to monitor DNA binding, translocation, and unwinding by iron-sulfur cluster containing helicases. Methods. 2010 Feb 16.
89(1,1,1,9) Details
19442249 White MF: Structure, function and evolution of the XPD family of iron-sulfur-containing 5'--> 3' DNA helicases. Biochem Soc Trans. 2009 Jun;37(Pt 3):547-51.
72(0,2,3,7) Details
19748362 Honda M, Park J, Pugh RA, Ha T, Spies M: Single-molecule analysis reveals differential effect of ssDNA-binding proteins on DNA translocation by XPD helicase. Mol Cell. 2009 Sep 11;35(5):694-703.

Distance-dependent fluorescence quenching by the iron-sulfur cluster of the archaeal XPD (Rad3) helicase was used as a calibrated proximity signal.
8(0,0,1,3) Details