Protein Information

Name CYC1
Synonyms CYC 1; CYC1; Cytochrome C1; Cytochrome c 1; Cytochrome C1s; Cytochrome c 1s

Compound Information

Name sulfur
CAS sulfur

Reference List

PubMed Abstract RScore(About this table)
19415898 Sarewicz M, Dutka M, Froncisz W, Osyczka A: Magnetic interactions sense changes in distance between heme b (L) and the iron-sulfur cluster in cytochrome bc (1). Biochemistry. 2009 Jun 23;48(24):5708-20.

During the operation of cytochrome bc (1), a key enzyme of biological energy conversion, the iron-sulfur head domain of one of the subunits of the catalytic core undergoes a large-scale movement from the catalytic quinone oxidation Q (o) site to cytochrome c (1).
81(1,1,1,1) Details
19917265 Cieluch E, Pietryga K, Sarewicz M, Osyczka A: Visualizing changes in electron distribution in coupled chains of cytochrome bc (1) by modifying barrier for electron transfer between the FeS cluster and heme c (1). Biochim Biophys Acta. 2010 Feb;1797(2):296-303. Epub 2009 Nov 14.


Cytochrome c (1) of Rhodobacter (Rba.) species provides a series of mutants which change barriers for electron transfer through the cofactor chains of cytochrome bc (1) by modifying heme c (1) redox midpoint potential.
2(0,0,0,2) Details
20008079 Ihrig J, Hausmann A, Hain A, Richter N, Hamza I, Lill R, Muhlenhoff U: Iron regulation through the back door: iron-dependent metabolite levels contribute to transcriptional adaptation to iron deprivation in Saccharomyces cerevisiae. Eukaryot Cell. 2010 Mar;9(3):460-71. Epub 2009 Dec 11.

Synthesis of alpha-isopropylmalate involves the iron-sulfur protein Ilv3, which is inactivated under iron deficiency.
As another example, decreased mRNA levels of the cytochrome c-encoding CYC1 gene under iron-limiting conditions involve heme-dependent transcriptional regulation via the Hap1 transcription factor.
1(0,0,0,1) Details