Protein Information

Name succinate dehydrogenase (protein family or complex)
Synonyms Succinate dehydrogenase; Succinate dehydrogenases

Compound Information

Name sulfur
CAS sulfur

Reference List

PubMed Abstract RScore(About this table)
19932106 Popov VN, Eprintsev AT, Fedorin DN, Igamberdiev AU: Succinate dehydrogenase in Arabidopsis thaliana is regulated by light via phytochrome A. FEBS Lett. 2010 Jan 4;584(1):199-202. Epub .

2(0,0,0,2) Details
20097860 Albrecht AG, Netz DJ, Miethke M, Pierik AJ, Burghaus O, Peuckert F, Lill R, Marahiel MA: SufU is an essential iron-sulfur cluster scaffold protein in Bacillus subtilis. J Bacteriol. 2010 Mar;192(6):1643-51. Epub 2010 Jan 22.

Bacteria use three distinct systems for iron-sulfur (Fe/S) cluster biogenesis: the ISC, SUF, and NIF machineries.
The drastic growth retardation of a conditional mutant depleted of SufU was coupled with a severe reduction of aconitase and succinate dehydrogenase activities in total-cell lysates, suggesting a crucial function of SufU in Fe/S protein biogenesis.
1(0,0,0,1) Details
19492851 Kim JH, Fuzery AK, Tonelli M, Ta DT, Westler WM, Vickery LE, Markley JL: Structure and dynamics of the iron-sulfur cluster assembly scaffold protein IscU and its interaction with the cochaperone HscB. Biochemistry. 2009 Jul 7;48(26):6062-71.

Its critical importance has been recently underscored by the finding that a single intronic mutation in the human iscu gene is associated with a myopathy resulting from deficient succinate dehydrogenase and aconitase [Mochel, F., Knight, M.
1(0,0,0,1) Details
19567699 Kollberg G, Tulinius M, Melberg A, Darin N, Andersen O, Holmgren D, Oldfors A, Holme E: Clinical manifestation and a new ISCU mutation in iron-sulphur cluster deficiency myopathy. Brain. 2009 Aug;132(Pt 8):2170-9. Epub 2009 Jun 30.


Myopathy with deficiency of succinate dehydrogenase and aconitase is a recessively inherited disorder characterized by childhood-onset early fatigue, dyspnoea and palpitations on trivial exercise.
1(0,0,0,1) Details
19466416 Ando A, Sakuradani E, Horinaka K, Ogawa J, Shimizu S: Transformation of an oleaginous zygomycete Mortierella alpina 1S-4 with the carboxin resistance gene conferred by mutation of the iron-sulfur subunit of succinate dehydrogenase. Curr Genet. 2009 Jun;55(3):349-56. Epub 2009 May 23.

The sdhB gene encoding an iron-sulfur (Ip) subunit of succinate dehydrogenase (SDH, EC 1.3.99.1) complex was cloned from Mortierella alpina 1S-4.
37(0,1,2,2) Details
20201001 Zhang YJ, Li J, Zhao W, Zhou MG: A single amino acid substitution in the SdhB protein of succinate dehydrogenase determines resistance to amicarthiazol in Xanthomonas oryzae pv. oryzae. Pest Manag Sci. 2010 Mar 3.

2(0,0,0,2) Details
19865480 Xu XM, Lin H, Latijnhouwers M, Moller SG: Dual localized AtHscB involved in iron sulfur protein biogenesis in Arabidopsis. PLoS One. 2009 Oct 29;4(10):e7662.

Furthermore, AtHscB is highly expressed in anthers and trichomes and an AtHscB T-DNA insertion mutant shows reduced seed set, a waxless phenotype and inappropriate trichome development as well as dramatically reduced activities of the iron-sulfur enzymes aconitase and succinate dehydrogenase.
31(0,1,1,1) Details
19864422 Song D, Tu Z, Lee FS: Human ISCA1 interacts with IOP1/NARFL and functions in both cytosolic and mitochondrial iron-sulfur protein biogenesis. J Biol Chem. 2009 Dec 18;284(51):35297-307. Epub .

We observe that small interfering RNA knockdown of IscA1 in HeLa cells leads to decreased activity of two mitochondrial iron-sulfur enzymes, succinate dehydrogenase and mitochondrial aconitase, as well as a cytosolic iron-sulfur enzyme, cytosolic aconitase.
31(0,1,1,1) Details