Protein Information

Name IL 6
Synonyms 26 kd protein; B cell differentiation factor; B cell stimulatory factor 2; BSF 2; BSF2; CDF; CTL differentiation factor; HGF…

Compound Information

Name sulfur
CAS sulfur

Reference List

PubMed Abstract RScore(About this table)
19748599 Pourfarzam S, Ghazanfari T, Yaraee R, Ghasemi H, Hassan ZM, Faghihzadeh S, Ardestani SK, Kariminia A, Fallahi F, Soroush MR, Merasizadeh J, Mahlojirad M, Naghizadeh MM, Ghanei M: Serum levels of IL-8 and IL-6 in the long term pulmonary complications induced by sulfur mustard: Sardasht-Iran Cohort Study. Int Immunopharmacol. 2009 Dec;9(13-14):1482-8. Epub 2009 Sep 11.
11(0,0,1,6) Details
20056584 Thompson AM, Zanobetti A, Silverman F, Schwartz J, Coull B, Urch B, Speck M, Brook JR, Manno M, Gold DR: Baseline repeated measures from controlled human exposure studies: associations between ambient air pollution exposure and the systemic inflammatory biomarkers IL-6 and fibrinogen. Environ Health Perspect. 2010 Jan;118(1):120-4.

Hourly and daily moving averages were calculated for ozone, nitrogen dioxide, sulfur dioxide, and particulate matter
7(0,0,0,7) Details
19776584 Lee JS, Kwon KA, Jung HS, Kim JH, Hahm KB: Korea red ginseng on Helicobacter pylori-induced halitosis: newer therapeutic strategy and a plausible mechanism. Digestion. 2009;80(3):192-9. Epub 2009 Sep 16.

BACKGROUND: Gas chromatographic documentation of volatile sulfur compounds in Helicobacter pylori cultures and the amelioration of halitosis after eradication suggested a causal link between H. pylori infection and halitosis.
The expressions of cystathionine gamma-lyase (CSE), cystathionine beta-synthetase (CBS), IL-6, IL-8 and IL-1beta mRNA were compared in H. pylori-infected or NaHS-treated gastric epithelial cells according to red ginseng treatment.
2(0,0,0,2) Details
19847372 Huang XL, Zhou JL, Zhou XH, Xian XH, Ding CH: [Ameliorative effects of exogenous sulfur dioxide on lipopolysaccharide-induced acute lung injury in rats.]. Sheng Li Xue Bao. 2009 Oct 25;61(5):499-503.

The number of polymorphonuclear neutrophil (PMN) in the bronchoalveolar lavage fluid (BALF), intercellular adhesion factor-1 (ICAM-1) expression in the lung tissue and IL-1, IL-6 and IL-10 levels in the serum were tested.
3(0,0,0,3) Details
19733692 Ghasemi H, Ghazanfari T, Yaraee R, Ghassemi-Broumand M, Soroush MR, Pourfarzam S, Masdari Z, Faghihzadeh S, Babaei M, Javadi MA, Kiuchi Y, Naghizadeh MM, Owlia P, Hassan ZM: Evaluation of relationship between the serum levels of inflammatory mediators and ocular injuries induced by sulfur mustard: Sardasht-Iran Cohort Study. Int Immunopharmacol. 2009 Dec;9(13-14):1494-8. Epub 2009 Sep 4.

The serum levels of IL-6 in the exposed group with or without Slit lamp findings were significantly lower than their counterpart in the control group (P=0.048 and 0.008 respectively).
1(0,0,0,1) Details
19440509 Liu L, Poon R, Chen L, Frescura AM, Montuschi P, Ciabattoni G, Wheeler A, Dales R: Acute effects of air pollution on pulmonary function, airway inflammation, and oxidative stress in asthmatic children. Environ Health Perspect. 2009 Apr;117(4):668-74. Epub 2008 Nov 28.

Daily ambient concentrations of sulfur dioxide, nitrogen dioxide, ozone, and particulate matter < or = 2.5 microm in aerodynamic diameter (PM (2.5)) were monitored from two stations.
Once a week we measured spirometry and fractional exhaled nitric oxide (FeNO), and determined thiobarbituric acid reactive substances (TBARS) and 8-isoprostane--two oxidative stress markers--and interleukin-6 (IL-6) in breath condensate.
1(0,0,0,1) Details
19651324 Kehe K, Balszuweit F, Steinritz D, Thiermann H: Molecular toxicology of sulfur mustard-induced cutaneous inflammation and blistering. Toxicology. 2009 Sep 1;263(1):12-9. Epub 2009 Jan 23.

Additionally, SM upregulates many inflammatory mediators including interleukin (IL)-1alpha, IL-1beta, IL-6, IL-8, tumor necrosis factor-alpha (TNF-alpha) and others.
1(0,0,0,1) Details
19733693 Amiri S, Ghazanfari T, Yaraee R, Salimi H, Ebtekar M, Shams J, Ghasemi H, Pourfarzam S, Moin A, Sharifnia Z, Soroush MR, Faghihzadeh S, Hassan ZM: Serum levels of GM-CSF 20 years after sulfur mustard exposure: Sardasht-Iran Cohort Study. Int Immunopharmacol. 2009 Dec;9(13-14):1499-503. Epub 2009 Sep 4.

Moreover, positive correlations were found between circulating levels of GM-CSF with IL-1alpha, IL-1beta, TNF-alpha and IL-6.
1(0,0,0,1) Details
19336900 Kim YH, Kim DH, Lim H, Baek DY, Shin HK, Kim JK: The anti-inflammatory effects of methylsulfonylmethane on lipopolysaccharide-induced inflammatory responses in murine macrophages. Biol Pharm Bull. 2009 Apr;32(4):651-6.

Methylsulfonylmethane (MSM), also known as dimethyl sulfone and methyl sulfone, is an organic sulfur-containing compound that occurs naturally in a variety of fruits, vegetables, grains, and animals, including humans.
Furthermore, the levels of interleukin-6 and tumor necrosis factor-alpha were decreased by MSM treatment in cell culture supernatants.
1(0,0,0,1) Details
19748996 Pohl C, Papritz M, Moisch M, Wubbeke C, Hermanns MI, Uboldi C, Dei-Anang J, Mayer E, Kirkpatrick CJ, Kehe K: Acute morphological and toxicological effects in a human bronchial coculture model after sulfur mustard exposure. Toxicol Sci. 2009 Dec;112(2):482-9. Epub 2009 Sep 11.

Changes in the proinflammatory cytokines interleukin (IL)-6 and IL-8 were also observed.
1(0,0,0,1) Details
19572781 Wigenstam E, Rocksen D, Ekstrand-Hammarstrom B, Bucht A: Treatment with dexamethasone or liposome-encapsuled vitamin E provides beneficial effects after chemical-induced lung injury. Inhal Toxicol. 2009 Sep;21(11):958-64.

The pathogenesis of lung injury by exposure to highly toxic sulfur and nitrogen mustards involves alkylating damage of the respiratory epithelium followed by an acute inflammatory response and lung edema.
A single intraperitoneal injection of dexamethasone (10 mg/kg body weight) 1 hour after melphalan exposure significantly reduced interleukin (IL)-1 and IL-6 in bronchoalveolar lavage fluid (BALF) and diminished the acute airway inflammation.
1(0,0,0,1) Details