Protein Information

Name lactate dehydrogenase (protein family or complex)
Synonyms LDH; lactate dehydrogenase; lactate dehydrogenases

Compound Information

Name cypermethrin
CAS cyano(3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate

Reference List

PubMed Abstract RScore(About this table)
12858966 Kamalaveni K, Gopal V, Sampson U, Aruna D: Recycling and utilization of metabolic wastes for energy production is an index of biochemical adaptation of fish under environmental pollution stress. Environ Monit Assess. 2003 Aug;86(3):255-64.

The activity levels of lactate dehydrogenase and lactic acid were assessed in various tissues of the fish during exposure to lethal concentration of group-II Pyrethroids (deltamethrin, cypermethrin, fenvalerate and fluvalinate) for a period of 72 hours.
7(0,0,1,2) Details
8521784 Philip GH, Reddy PM, Sridevi G: Cypermethrin-induced in vivo alterations in the carbohydrate metabolism of freshwater fish, Labeo rohita. Ecotoxicol Environ Saf. 1995 Jul;31(2):173-8.

Activity of lactate dehydrogenase was elevated, indicating a shift toward anaerobiosis.
1(0,0,0,1) Details
12524023 Das BK, Mukherjee SC: Toxicity of cypermethrin in Labeo rohita fingerlings: biochemical, enzymatic and haematological consequences. Comp Biochem Physiol C Toxicol Pharmacol. 2003 Jan;134(1):109-21.

Lactate dehydrogenase activity in brain and liver was elevated, but inhibited in kidney.
1(0,0,0,1) Details
15365239 Manna S, Bhattacharyya D, Mandal TK, Das S: Repeated dose toxicity of alfa-cypermethrin in rats. J Vet Sci. 2004 Sep;5(3):241-5.

It increased the serum aminotransaminases (AST, ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) activities and blood glucose level significantly. alpha-CP decreased RBC count, PCV and Hb level significantly.
1(0,0,0,1) Details
14630057 Grajeda-Cota P, Ramirez-Mares MV, Gonzalez de Mejia E: Vitamin C protects against in vitro cytotoxicity of cypermethrin in rat hepatocytes. Toxicol In Vitro. 2004 Feb;18(1):13-9.

In vitro cell viability, lactate dehydrogenase (LDH), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) leakage were measured, as indicators of hepatic damage, at 1, 15 and 30 min of exposure to CM.
1(0,0,0,1) Details
2466999 Shakoori AR, Ali SS, Saleem MA: Effects of six months' feeding of cypermethrin on the blood and liver of albino rats. J Biochem Toxicol. 1988 Spring;3:59-71.

The blood serum lactate dehydrogenase (LDH), isocitrate dehydrogenase (ICDH), and amylase activities were elevated 61%, 30%, and 46%, respectively, after six months of insecticide feeding, suggesting liver and possibly pancreas malfunction.
1(0,0,0,1) Details
1872878 Reddy AT, Yellamma K: Perturbations in carbohydrate metabolism during cypermethrin toxicity in fish, Tilapia mossambica. Biochem Int. 1991 Mar;23(4):633-8.

A decrease in lactate dehydrogenase activity with increase in lactate levels suggests reduced mobilization of pyruvate into citric acid cycle.
1(0,0,0,1) Details
17159788 Dobsikova R, Velisek J, Wlasow T, Gomulka P, Svobodova Z, Novotny L: Effects of cypermethrin on some haematological, biochemical and histopathological parameters of common carp (Cyprinus carpio L.). Neuro Endocrinol Lett. 2006 Dec;27 Suppl 2:91-5.

As far as biochemical indices are concerned, the exposure caused a significant (P <0.01) increase in glucose and lactate concentration and creatine kinase activity, and a significant (P <0.01) decrease in total proteins, albumins, total globulins, ammonia, lactate dehydrogenase and alkaline phosphatase in blood plasma of exposed carp compared to the control group.
1(0,0,0,1) Details
19581076 Aslam F, Khan A, Khan MZ, Sharaf S, Gul ST, Saleemi MK: Toxico-pathological changes induced by cypermethrin in broiler chicks: Their attenuation with Vitamin E and selenium. Exp Toxicol Pathol. 2009 Jul 4.

Total plasma proteins, fibrinogen and creatinine were significantly (P <0.05) increased while alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and urea decreased significantly (P <0.05) in CY-treated group when compared with the control group.
1(0,0,0,1) Details