| Name | immunophilin |
|---|---|
| Synonyms | 36 kDa FK506 binding protein; PPIase; Rotamase; Peptidyl prolyl cis trans isomerase; Peptidylprolyl cis trans isomerase; FK506 binding protein 6; FK506 binding protein 6 isoform; FK506 binding protein 6 (36kD)… |
| Name | cypermethrin |
|---|---|
| CAS | cyano(3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9714322 | Fakata KL, Swanson SA, Vorce RL, Stemmer PM: Pyrethroid insecticides as phosphatase inhibitors. . Biochem Pharmacol. 1998 Jun 15;55(12):2017-22. In this study we tested the hypothesis that pyrethroid insecticides inhibit calcineurin directly and that inhibition is unaffected by the immunophilin cofactors necessary for calcineurin inhibition by cyclosporin A and FK506. The type II pyrethroid insecticides cis-cypermethrin (c-Cyp), trans-cypermethrin, deltamethrin (Delt), and fenvalerate A alpha (Fen), as well as the type I pyrethroid insecticides cis- and trans-permethrin and S-bioallethrin, were unable to inhibit the phosphatase activity of purified calcineurin under conditions of maximal activation by Ca2+ and calmodulin. |
1(0,0,0,1) | Details |
| 10463953 | Alexanian AR, Bamburg JR: Neuronal survival activity of s100betabeta is enhanced by calcineurin inhibitors and requires activation of NF-kappaB. FASEB J. 1999 Sep;13(12):1611-20. Cypermethrin, a direct and highly specific calcineurin inhibitor, mimicked the immunophilin ligands in its neurotrophic effect. |
31(0,1,1,1) | Details |
| 19243469 | Hui KK, Liadis N, Robertson J, Kanungo A, Henderson JT: Calcineurin inhibition enhances motor neuron survival following injury. J Cell Mol Med. 2009 Feb 20. However each drug-immunophilin complex can potentially influence additional signal transduction pathways. To examine the mechanism responsible for neuroprotection by these agents, pharmacologic inhibitors of several potential alternate signaling pathways (17-(allylamino)-17-demethoxygeldanamycin, rapamycin, cypermethrin) were evaluated with respect to neuroprotection. |
2(0,0,0,2) | Details |
| 20139366 | Rosado JA, Pariente JA, Salido GM, Redondo PC: SERCA2b activity is regulated by cyclophilins in human platelets. . Arterioscler Thromb Vasc Biol. 2010 Mar;30(3):419-25. Epub 2010 Feb 5. Cypermethrin, a non-CsA-related calcineurin inhibitor, did not alter SERCA2b activity. |
0(0,0,0,0) | Details |