Protein Information

Name ATPases
Synonyms (NA+ + K+)ATPase; ATP1A1; ATPase; ATPase Na+/K+ transporting alpha 1 polypeptide; Na (+) K (+) ATPase; Na (+),K (+) ATPase; Na + K + ATPase; Na K + ATPase…

Compound Information

Name cypermethrin
CAS cyano(3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate

Reference List

PubMed Abstract RScore(About this table)
10571459 Bendahou N, Bounias M, Fleche C: Toxicity of cypermethrin and fenitrothion on the hemolymph carbohydrates, head acetylcholinesterase, and thoracic muscle Na+, K+-ATPase of emerging honeybees (Apis mellifera mellifera. Ecotoxicol Environ Saf. 1999 Oct;44(2):139-46.

Na+, K+-ATPases activity was significantly inhibited (P < 0.05) by cypermethrin and maximum percentage inhibition was reached (45%) at 1 nmol/bee.
87(1,1,2,2) Details
19823759 Prashanth MS, David M: Impact of cypermethrin on Na (+)-K (+), Ca (2+) and Mg (2+) ATPases in Indian major carp, Cirrhinus mrigala (Hamilton). Bull Environ Contam Toxicol. 2010 Jan;84(1):80-4. Epub 2009 Oct 13.
7(0,0,1,2) Details
12615099 Kakko I, Toimela T, Tahti H: The synaptosomal membrane bound ATPase as a target for the neurotoxic effects of pyrethroids, permethrin and cypermethrin. Chemosphere. 2003 May;51(6):475-80.

The results support the idea that membrane ATPases are one target of the neurotoxic effect of pyrethroid compounds.
1(0,0,0,1) Details
8721628 Philip GH, Anuradha J: Role of phosphatases during transport and energy metabolism in Labeo rohita after exposure to cypermethrin. Biomed Environ Sci. 1996 Mar;9(1):52-9.

Ionic regulation and energy requirements were also found to be altered under stress, as observed by the inhibition of both Na+/K+ and Mg2+ ATPases at 7d EP and elevation at 15d EP.
1(0,0,0,1) Details