| 19631535 |
Simeone JP, Braun MP, Leone JF, Lin P, DeVita RJ, Garcia-Calvo M, Bull HG, Lisnock J, Dean DC: Multiple strategies for the preparation of a sulfur-35 labeled NPC1L1 radioligand. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5033-6. Epub 2009 Jul 22.
During our effort to design a receptor binding assay to aid in the elucidation of the molecular mechanism of ezetimibe, we prepared a sulfur-35 containing radioligand which exhibits improved potency over the glucuronide conjugate of ezetimibe in both native enterocyte brush border membranes and membranes from cells expressing recombinant NPC1L1. |
87(1,1,2,2) |
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