| Name | N methyl D aspartate receptor (protein family or complex) |
|---|---|
| Synonyms | Glutamate [NMDA] receptor; Glutamate [NMDA] receptors; N methyl D aspartate receptor; N methyl D aspartate receptors; NMDA receptor; NMDA receptors |
| Name | cypermethrin |
|---|---|
| CAS | cyano(3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17721829 | Lin YW, Yang HW, Min MY, Chiu TH: Inhibition of associative long-term depression by activation of beta-adrenergic receptors in rat hippocampal CA1 synapses. J Biomed Sci. 2008 Jan;15(1):123-31. Epub 2007 Aug 27. The associative LTD of weak pathway was NMDA receptor- and phosphatase 2B dependent, because bath application of 50 microM D, L-AP5 or 10 microM cypermethrin blocked its induction. |
31(0,1,1,1) | Details |
| 7870309 | Stelzer A, Shi H: Impairment of GABAA receptor function by -mediated influx in isolated CA1 pyramidal cells. Neuroscience. 1994 Oct;62(3):813-28. -mediated suppression of GABAA currents was significantly less expressed when intracellular ATP was replaced by its analog 5'-O-(3-thiotriphosphate) and when the specific phosphatase 2B inhibitor cypermethrin was added intracellularly. N-methyl-D-aspartate receptor-mediated currents were used as conditioning source of influx. |
3(0,0,0,3) | Details |
| 8727406 | Wang JH, Stelzer A: Shared signaling pathways in the induction of long-term potentiation and synaptic disinhibition in CA1 pyramidal cell dendrites. J Neurophysiol. 1996 Apr;75(4):1687-702. A role of NMDA receptors in induction of long-term synaptic disinhibition was tested by preventing NMDA receptor activation 1) by pharmacological means and 2) by holding the membrane clamped at -80 mV (in dSEVC) during tetanization. In recordings in which the intracellular pipette was preloaded with cypermethrin, a potent and selective inhibitor of phosphatase 2B, respective long-term changes of synaptic transmission (increases of excitation, decreases of synaptic inhibition) were prevented. |
2(0,0,0,2) | Details |
| 16139540 | Shin DS, Wilkie MP, Pamenter ME, Buck LT: and protein phosphatase 1/2A attenuate N-methyl-D-aspartate receptor activity in the anoxic turtle cortex. Comp Biochem Physiol A Mol Integr Physiol. 2005 Sep;142(1):50-7. However, cypermethrin, an inhibitor of the Ca (2+)/calmodulin-dependent PP2B (calcineurin), abolished the anoxic decrease in NMDAR activity at 20, but not 40 min suggesting that this phosphatase might play an early role in attenuating NMDAR activity during anoxia. |
2(0,0,0,2) | Details |
| 17008368 | Yang CH, Huang CC, Hsu KS: Novelty exploration elicits a reversal of acute stress-induced modulation of hippocampal synaptic plasticity in the rat. J Physiol. 2006 Dec 1;577(Pt 2):601-15. Epub 2006 Sep 28. Novelty exploration-induced reversal of stress effects was prevented when the animals were given the NMDA receptor antagonist D-(-)-2-amino-5-phosphonopentanoic acid, the cholinergic antagonist atropine and the protein phosphatase (PP) 2B inhibitors cyclosporin A and cypermethrin, but not the alpha1-adrenergic antagonist prazosin, the beta-adrenergic antagonist or the PP1/2A inhibitor okadaic acid, respectively before being subjected to the novel environment. Taken together, these findings suggest that the activation of the cholinergic system and, in turn, the triggering of an NMDA receptor-mediated activation of PP2B to increase STEP activity appear to mediate the novelty exploration-induced reversal of stress-related modulation of hippocampal long-term synaptic plasticity. |
1(0,0,0,1) | Details |
| 7881062 | Wang JH, Stelzer A: Inhibition of phosphatase 2B prevents expression of hippocampal long-term potentiation. Neuroreport. 1994 Nov 21;5(17):2377-80. The induction of long-term potentiation (LTP) in the CA1 region of the hippocampus is mediated by (NMDA) receptor-coupled influx. In dendrites in which cypermethrin, a potent and specific inhibitor of PP-2B (IC50 40 pM), was intracellularly applied, tetanization generated only short-term increases (15-30 min) of excitatory responses. |
1(0,0,0,1) | Details |