| Name | dopamine transporter |
|---|---|
| Synonyms | DA transporter; DAT1; DAT; DAT 1; Dopamine transporter; SLC6A3; Sodium dependent dopamine transporter; Dopamine transporters… |
| Name | dieldrin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17291500 | Hatcher JM, Richardson JR, Guillot TS, McCormack AL, Di Monte DA, Jones DP, Pennell KD, Miller GW: Dieldrin exposure induces oxidative damage in the mouse nigrostriatal system. Exp Neurol. 2007 Apr;204(2):619-30. Epub 2007 Jan 5. Finally, dieldrin caused a significant decrease in striatal expression of the dopamine transporter as measured by (3) H-WIN 35,428 binding and (3) H- uptake. |
31(0,1,1,1) | Details |
| 16809432 | Richardson JR, Caudle WM, Wang M, Dean ED, Pennell KD, Miller GW: Developmental exposure to the pesticide dieldrin alters the system and increases neurotoxicity in an animal model of Parkinson's disease. FASEB J. 2006 Aug;20(10):1695-7. Epub 2006 Jun 29. At 12 wk of age, protein and mRNA levels of the dopamine transporter (DAT) and vesicular monoamine transporter 2 (VMAT2) were increased by perinatal dieldrin exposure in a dose-related manner. |
6(0,0,1,1) | Details |
| 11719704 | Purkerson-Parker S, McDaniel KL, Moser VC: Dopamine transporter binding in the rat striatum is increased by gestational, perinatal, and adolescent exposure to heptachlor. Toxicol Sci. 2001 Dec;64(2):216-23. Adolescent exposure to dieldrin was included to evaluate the generality of the findings. |
2(0,0,0,2) | Details |
| 18533268 | Hatcher JM, Delea KC, Richardson JR, Pennell KD, Miller GW: Disruption of transport by DDT and its metabolites. . Neurotoxicology. 2008 Jul;29(4):682-90. Epub 2008 Apr 29. Although studies have been unable to clearly identify specific pesticides that contribute to PD, a few human studies have reported higher levels of the organochlorine pesticides dieldrin and DDE (a metabolite of DDT) in post-mortem PD brains. In vitro analyses in mouse synaptosomes and vesicles demonstrated that DDT and its metabolites inhibit the plasma membrane dopamine transporter (DAT) and the vesicular monoamine transporter (VMAT2). |
1(0,0,0,1) | Details |
| 19479021 | Alyea RA, Watson CS: Differential regulation of dopamine transporter function and location by low concentrations of environmental estrogens and 17beta- Environ Health Perspect. 2009 May;117(5):778-83. Epub 2009 Jan 5. OBJECTIVE: We examined low concentrations of XEs [dieldrin, endosulfan, o', p'-dichlorodiphenyl-ethylene (DDE), nonylphenol (NP), and bisphenol A (BPA)] for nongenomic actions via action of membrane estrogen receptors (ERs). |
2(0,0,0,2) | Details |