Protein Information

Name NADH:ubiquinone oxidoreductase (protein family or complex)
Synonyms NADH ubiquinone oxidoreductase; NADH ubiquinone oxidoreductases; NADH:ubiquinone oxidoreductase; NADH:ubiquinone oxidoreductases

Compound Information

Name sulfur
CAS sulfur

Reference List

PubMed Abstract RScore(About this table)
19961238 Shinzawa-Itoh K, Seiyama J, Terada H, Nakatsubo R, Naoki K, Nakashima Y, Yoshikawa S: Bovine heart NADH-ubiquinone oxidoreductase contains one molecule of ubiquinone with ten isoprene units as one of the cofactors. Biochemistry. 2010 Jan 26;49(3):487-92.

An improved purification method including solubilization of mitochondrial membrane with deoxycholate followed by sucrose gradient centrifugation and anion-exchange column chromatography provided reproducibly a heme-free preparation containing 1 Q (10), 70 phosphorus atoms of phospholipids, 1 zinc ion, 1 FMN, 30 inorganic sulfur ions, and 30 iron atoms as the intrinsic constituents.
2(0,0,0,2) Details
19366614 Zickermann V, Kerscher S, Zwicker K, Tocilescu MA, Radermacher M, Brandt U: Architecture of complex I and its implications for electron transfer and proton pumping. Biochim Biophys Acta. 2009 Jun;1787(6):574-83. Epub 2009 Feb 7.

Proton pumping NADH:ubiquinone oxidoreductase (complex I) is the largest and remains by far the least understood enzyme complex of the respiratory chain.
The ubiquinone reduction site close to iron-sulfur cluster N2 at the interface of the 49-kDa and PSST subunits has been mapped by extensive site directed mutagenesis.
1(0,0,0,1) Details
19752196 Sheftel AD, Stehling O, Pierik AJ, Netz DJ, Kerscher S, Elsasser HP, Wittig I, Balk J, Brandt U, Lill R: Human ind1, an iron-sulfur cluster assembly factor for respiratory complex I. Mol Cell Biol. 2009 Nov;29(22):6059-73. Epub 2009 Sep 14.

Respiratory complex I (NADH:ubiquinone oxidoreductase) is a large mitochondrial inner membrane enzyme consisting of 45 subunits and 8 iron-sulfur (Fe/S) clusters.
6(0,0,1,1) Details
19366602 Maly T, Zwicker K, Cernescu A, Brandt U, Prisner TF: New pulsed EPR methods and their application to characterize mitochondrial complex I. Biochim Biophys Acta. 2009 Jun;1787(6):584-92. Epub 2009 Feb 12.

Here we give an overview of the use of pulsed EPR spectroscopy to study the iron-sulfur clusters of NADH:ubiquinone oxidoreductase (complex I).
6(0,0,1,1) Details