Protein Information

Name neurotrophin
Synonyms Abrineurin; BDNF; Brain derived neurotrophic factor; Brain derived neurotrophic factor precursor; Neurotrophin; Brain derived neurotrophic factors; Brain derived neurotrophic factor precursors; Neurotrophins

Compound Information

Name dieldrin
CAS

Reference List

PubMed Abstract RScore(About this table)
18452993 Cho HS, Kim S, Lee SY, Park JA, Kim SJ, Chun HS: Protective effect of the green tea component, L-theanine on environmental toxins-induced neuronal cell death. Neurotoxicology. 2008 Jul;29(4):656-62. Epub 2008 Mar 20.

In this study, we investigated the protective effects of L-theanine on neurotoxicity induced by PD-related neurotoxicants, rotenone and dieldrin in cultured human dopaminergic cell line, SH-SY5Y.
Furthermore, pretreatment with L-theanine significantly attenuated the down-regulation of brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) production in SH-SY5Y cells.
1(0,0,0,1) Details
19130878 Slotkin TA, Seidler FJ, Fumagalli F: Unrelated developmental neurotoxicants elicit similar transcriptional profiles for effects on neurotrophic factors and their receptors in an in vitro model. Neurotoxicol Teratol. 2010 Jan-Feb;32(1):42-51. Epub 2008 Dec 13.

We examined an organophosphate pesticide (diazinon), an organochlorine pesticide (dieldrin) and a metal (Ni (2+)) for effects on the expression of neurotrophic factors and their receptors and modulators in differentiating PC12 cells, an in vitro model of neuronal development.
Using microarrays, we examined the mRNAs encoding members of the fibroblast growth factor (fgf) family, the neurotrophins (ntfs), brain-derived neurotrophic factor (bdnf), nerve growth factor (ngf), the wnt and fzd gene families, and the receptors and modulators for each class.
1(0,0,0,1) Details
19173004 Cameron HL, Foster WG: Developmental and lactational exposure to dieldrin alters mammary tumorigenesis in Her2/neu transgenic mice. PLoS One. 2009;4(1):e4303. Epub 2009 Jan 28.

Increased mRNA and protein expression of the neurotrophin BDNF and its receptor TrkB was increased in tumors from the offspring of dieldrin treated dams.
81(1,1,1,1) Details
18695511 Park JA, Kim S, Lee SY, Kim CS, Kim do K, Kim SJ, Chun HS: Beneficial effects of carnosic acid on dieldrin-induced dopaminergic neuronal cell death. Neuroreport. 2008 Aug 27;19(13):1301-4.

Furthermore, dieldrin-induced downregulation of brain-derived neurotrophic factor production was significantly attenuated by CA.
32(0,1,1,2) Details