Protein Information

Name tryptophan hydroxylase
Synonyms TPH; TPH2; TPH 1; TPH1; TPRH; TRPH; Tryptophan 5 hydroxylase; Tryptophan 5 hydroxylase 1…

Compound Information

Name dieldrin
CAS

Reference List

PubMed Abstract RScore(About this table)
18835401 Slotkin TA, Seidler FJ: Developmental neurotoxicants target neurodifferentiation into the serotonin phenotype: Chlorpyrifos, diazinon, dieldrin and divalent nickel. Toxicol Appl Pharmacol. 2008 Dec 1;233(2):211-9. Epub 2008 Sep 16.

Dieldrin evoked even stronger induction of tryptophan hydroxylase, and displayed a pattern of receptor effects similar to that of diazinon, even though they come from different pesticide classes.
33(0,1,1,3) Details
20211759 Kamata R, Shiraishi F, Takahashi S, Shimizu A, Shiraishi H: Reevaluation of the developmental toxicity of dieldrin by the use of fertilized Japanese quail eggs. Comp Biochem Physiol C Toxicol Pharmacol. 2010 Mar 6.

Other significant alterations in hatchlings were enlargement of the whole brain, decreases in mRNA expressions of tryptophan hydroxylase in the brainstem and cholesterol side-chain cleavage in the male gonad, and increases in mRNA expressions of cytochrome P450 1A and 2C18 in the liver.
1(0,0,0,1) Details