Protein Information

Name superoxide dismutase
Synonyms IPO B; Indophenoloxidase B; MNSOD; Manganese superoxide dismutase; Manganese containing superoxide dismutase; Mangano superoxide dismutase; Mn superoxide dismutase; Mn SOD…

Compound Information

Name dieldrin
CAS

Reference List

PubMed Abstract RScore(About this table)
12831855 Kitazawa M, Anantharam V, Kanthasamy AG: Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase Cdelta in dopaminergic cells: relevance to oxidative stress and dopaminergic degeneration. Neuroscience. 2003;119(4):945-64.

The superoxide dismutase mimetic Mn (III) tetrakis (4-benzoic acid) porphyrin chloride significantly attenuates dieldrin-induced cytochrome C release, indicating that reactive oxygen species may contribute to the activation of pro-apoptotic factors.
31(0,1,1,1) Details
9568359 Pedrajas JR, Lopez-Barea J, Peinado J: Dieldrin induces peroxisomal enzymes in fish (Sparus aurata) liver. . Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1996 Oct;115(2):125-31.

Thus, the effects of copper (II) were mainly in nucleus and cytosol, whereas dieldrin induced catalase and superoxide dismutase (up to 2.8-fold) preferentially in nucleus and LMF fractions.
9(0,0,1,4) Details
8548864 Pedrajas JR, Peinado J, Lopez-Barea J: Oxidative stress in fish exposed to model xenobiotics. Chem Biol Interact. 1995 Dec 22;98(3):267-82.

Oxidatively modified forms of Cu,Zn-superoxide dismutase as potential biomarkers..
The levels of soluble thiobarbituric acid reactive substances (TBARS) increased markedly in animals treated with polar xenobiotics, CuCl2 or paraquat; exposure to the apolar xenobiotics, dieldrin or malathion, enhanced significantly the microsomal TBARS while decreasing the microsomal glutathione transferase activity.
2(0,0,0,2) Details
9877197 Pedrajas JR, Gavilanes F, Lopez-Barea J, Peinado J: Incubation of superoxide dismutase with malondialdehyde and 4-hydroxy-2-nonenal forms new active isoforms and adducts. Chem Biol Interact. 1998 Nov 6;116(1-2):1-17.

The effects in fish (Sparus aurata) of dieldrin, previously reported to be an inducer of peroxisomal enzymes (Pedrajas et al., Comp.
2(0,0,0,2) Details
17623884 Sava V, Velasquez A, Song S, Sanchez-Ramos J: Dieldrin elicits a widespread DNA repair and antioxidative response in mouse brain. J Biochem Mol Toxicol. 2007;21(3):125-35.

Other measures of oxidative stress were also studied, including the regional distribution of lipid peroxidation and superoxide dismutase (SOD) activity.
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1321764 Tomkins PT, Molloy SM, Finnegan MT: Inhibition of superoxide dismutase is associated with reduced gap junctional intercellular communication in an in vitro system. Biochem Soc Trans. 1992 Feb;20(1):64S.

1(0,0,0,1) Details
2980962 Hunt RH: Location of genes on chromosome arms in the Anopheles gambiae group of species and their correlation to linkage data for other anopheline mosquitoes. Med Vet Entomol. 1987 Jan;1(1):81-8.


The gene for dieldrin resistance is assigned to chromosome 2 which in turn is correlated to the previous assignment of the gene to linkage group II.
0(0,0,0,0) Details
19440498 Slotkin TA, Seidler FJ: Oxidative and excitatory mechanisms of developmental neurotoxicity: transcriptional profiles for chlorpyrifos, diazinon, dieldrin, and divalent nickel in PC12 cells. Environ Health Perspect. 2009 Apr;117(4):587-96. Epub 2008 Dec 5.

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