| Name | Connexin 43 |
|---|---|
| Synonyms | CX43; Connexin 43; Cx43; DFNB38; GJA 1; GJA1; GJAL; Gap junction 43 kDa heart protein… |
| Name | dieldrin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15082077 | Fiorini C, Tilloy-Ellul A, Chevalier S, Charuel C, Pointis G: Sertoli cell junctional proteins as early targets for different classes of reproductive toxicants. Reprod Toxicol. 2004 May;18(3):413-21. Western blot and immunofluorescence analyses showed that SerW3 Sertoli cells expressed typical components of tight (occludin and zonula occludens-1), anchoring (N-cadherin) and gap (connexin 43) junctions. Testicular toxicants (DDT, pentachlorophenol, dieldrin, dinitrobenzene, cadmium cisplatin, gossypol, bisphenol A and tert-octylphenol) affected intercellular junctions by either reducing the amount or inducing aberrant intracellular localization of these membranous proteins. |
2(0,0,0,2) | Details |
| 18040759 | Sidorova TS, Matesic DF: Protective effect of the natural product, chaetoglobosin K, on lindane- and dieldrin-induced changes in astroglia: identification of activated signaling pathways. Pharm Res. 2008 Jun;25(6):1297-308. CONCLUSION: ChK's protective effects, both preventative and reversal, on lindane and dieldrin inhibition of gap junction-mediated communication are associated with stabilization and reappearance of the connexin 43 P2 phosphoform and may be mediated by the Akt pathway. |
113(1,2,2,3) | Details |
| 8068183 | Matesic DF, Rupp HL, Bonney WJ, Ruch RJ, Trosko JE: Changes in gap-junction permeability, phosphorylation, and number mediated by phorbol ester and non-phorbol-ester tumor promoters in rat liver epithelial cells. Mol Carcinog. 1994 Aug;10(4):226-36. The effects of three tumor promoters on gap-junction permeability; connexin 43 and 26 mRNA levels, protein levels, and phosphorylation; and the numbers of gap-junctional membrane plaques were studied in the rat liver epithelial cell line WB-F344 to determine whether changes in these parameters correlated with the inhibition of gap-junction function. 12-O-tetradecanoylphorbol-13- (TPA; 10 ng/mL), dieldrin (10 micrograms/mL), and heptachlor epoxide (10 micrograms/mL) inhibited gap-junctional intercellular communication (GJIC) assayed by fluorescent dye transfer by 80-90% after a 5-min exposure and by more than 90% within 1 h. |
35(0,1,1,5) | Details |
| 8820588 | Kang KS, Wilson MR, Hayashi T, Chang CC, Trosko JE: Inhibition of gap junctional intercellular communication in normal human breast epithelial cells after treatment with pesticides, PCBs, and PBBs, alone or in mixtures. Environ Health Perspect. 1996 Feb;104(2):192-200. The scrape-loading/dye transfer and fluorescent redistribution after photobleaching techniques were used to measure GJIC; immunostaining and Western and Northern analyses were performed on connexin 43 (Cx43) gap junction protein and message to determine how halogenated hydrocarbons might affect GJIC. DDT, dieldrin, and toxaphene inhibited GJIC in a dose-responsive manner after 90 min treatments. |
1(0,0,0,1) | Details |
| 11787861 | Matesic DF, Blommel ML, Sunman JA, Cutler SJ, Cutler HG: Prevention of organochlorine-induced inhibition of gap junctional communication by chaetoglobosin K in astrocytes. Cell Biol Toxicol. 2001;17(6):395-408. In this study, the organochlorine xenobiotics dieldrin and endosulfan, at micromolar concentrations, were found to inhibit gap junction-mediated intercellular communication and induce hypophosphorylation of connexin 43 in cultured rat astrocytes, the predominant cell type in the brain coupled through gap junctions. |
88(1,1,2,3) | Details |