| Name | pregnane X receptor |
|---|---|
| Synonyms | BXR; PAR; PAR1; NR1I2; ONR 1; ONR1; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR… |
| Name | dieldrin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12049174 | Wei P, Zhang J, Dowhan DH, Han Y, Moore DD: Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response. Pharmacogenomics J. 2002;2(2):117-26. Chlorpromazine induction of CYP3A11 is also absent in CAR-deficient animals, but the responses to and dieldrin are retained, indicating that both of these inducers can also activate PXR (Pregnane X Receptor NR112). |
81(1,1,1,1) | Details |
| 15358766 | Zhang J, Huang W, Qatanani M, Evans RM, Moore DD: The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity. J Biol Chem. 2004 Nov 19;279(47):49517-22. Epub 2004 Sep 8. As expected, they are completely insensitive to broad range xenobiotic inducers able to activate both receptors, such as and dieldrin. |
2(0,0,0,2) | Details |
| 12417264 | Coumoul X, Diry M, Barouki R: PXR-dependent induction of human CYP3A4 gene expression by organochlorine pesticides. Biochem Pharmacol. 2002 Nov 15;64(10):1513-9. In this study, we have performed Northern blot and transient transfection assays in various cell lines and shown that OCP activate human pregnane X receptor (PXR) and subsequent CYP3A4 mRNA expression. |
1(0,0,0,1) | Details |
| 16054614 | Kretschmer XC, Baldwin WS: CAR and PXR: xenosensors of endocrine disrupters? . Chem Biol Interact. 2005 Aug 15;155(3):111-28. The pregnane X-receptor (PXR) and the constitutive androstane receptor (CAR) are orphan nuclear receptors activated by a variety of ligands. Environmental estrogens, such as the pesticides methoxychlor, endosulfan, dieldrin, DDT, and the plasticizer nonylphenol activate either PXR or both PXR and CAR. |
1(0,0,0,1) | Details |