Protein Information

Name albumin
Synonyms ALB; Albumin; PRO0883; PRO0903; PRO1341; PRO1708; PRO2044; PRO2619…

Compound Information

Name dieldrin
CAS

Reference List

PubMed Abstract RScore(About this table)
6790724 Tanaka R, Fujisawa S, Nakai K: Study on the absorption and protein binding of carbaryl, dieldrin and paraquat in rats fed on protein diet. J Toxicol Sci. 1981 Feb;6(1):1-11.

In serum, dieldrin was bound to lipoproteins, globulins and partly to albumin.
82(1,1,1,2) Details
12049848 Gulden M, Morchel S, Tahan S, Seibert H: Impact of protein binding on the availability and cytotoxic potency of organochlorine pesticides and chlorophenols in vitro. Toxicology. 2002 Jun 14;175(1-3):201-13.

Calculated fractions bound to albumin in the normal growth medium were 0.075-0.17 (p,p'-DDT, p,p'-DDE, dieldrin, lindane), 0.09-0.1 (4-mono- and 2,4-dichlorophenol), 0.68 (2,4,5-trichlorphenol) and almost 1.0 (pentachlorophenol).
33(0,1,1,3) Details
6174734 Soine PJ, Blanke RV, Guzelian PS, Schwartz CC: Preferential binding of chlordecone to the protein and high density lipoprotein fractions of plasma from humans and other species. J Toxicol Environ Health. 1982 Jan;9(1):107-18.

Preferential binding of CD by albumin and HDL may explain its unusual tissue distribution compared to other organochlorine pesticides such as aldrin and dieldrin, which bind preferentially to VLDL and LDL and distribute preferentially to fat tissues.
32(0,1,1,2) Details
16580813 Gulden M, Dierickx P, Seibert H: Validation of a prediction model for estimating serum concentrations of chemicals which are equivalent to toxic concentrations in vitro. Toxicol In Vitro. 2006 Oct;20(7):1114-24. Epub 2006 Mar 6.


Necessary input data are in vitro toxic concentrations and distribution relevant system and substance specific parameters, e.g. lipid volume fractions and albumin concentrations, octanol/water partition coefficients and specific binding to albumin.
2(0,0,0,2) Details
6176662 Maliwal BP, Guthrie FE: In vitro uptake and transfer of chlorinated hydrocarbons among human lipoproteins. J Lipid Res. 1982 Mar;23(3):474-9.

The uptake, distribution, and exchange of chlorinated hydrocarbon insecticides (dieldrin and chlordecone) and biphenyls (2,4,5-2',4',5'-hexachlorobiphenyl and 3-chlorobiphenyl) among human lipoproteins was examined by fluorescence quenching, gel filtration, and ultrafiltration.
The chlorinated hydrocarbons attached to albumin or one of the lipoproteins were rapidly transferred to all other lipoproteins.
1(0,0,0,1) Details