Protein Information

Name heme oxygenase 1
Synonyms HMOX 1; HMOX1; HMOX1 protein; HO; HO 1; HO1; Heme oxygenase (Decycling) 1; Heme oxygenase (Decyclizing) 1…

Compound Information

Name dieldrin
CAS

Reference List

PubMed Abstract RScore(About this table)
15770161 Kim DK, Kim JS, Kim JE, Kim SJ, Lee JS, Kim DJ, Son JH, Chun HS: Heme oxygenase-1 induction by dieldrin in dopaminergic cells. Neuroreport. 2005 Apr 4;16(5):509-12.

Deletional and mutational analyses showed that the 5' distal enhancers, E1 and E2, mediate dieldrin-induced HO-1 gene transcription, and the AP-1 DNA binding sites in the E2 enhancer are critical for E2-mediated HO-1 gene activation.
211(2,3,6,6) Details
18452993 Cho HS, Kim S, Lee SY, Park JA, Kim SJ, Chun HS: Protective effect of the green tea component, L-theanine on environmental toxins-induced neuronal cell death. Neurotoxicology. 2008 Jul;29(4):656-62. Epub 2008 Mar 20.

In addition, L-theanine partially prevented both rotenone- and dieldrin-induced heme oxygenase-1 (HO-1) up-regulation.
6(0,0,1,1) Details
11181820 Chun HS, Gibson GE, DeGiorgio LA, Zhang H, Kidd VJ, Son JH: Dopaminergic cell death induced by MPP (+), oxidant and specific neurotoxicants shares the common molecular mechanism. J Neurochem. 2001 Feb;76(4):1010-21.

Epidemiological risk factor analyses of typical PD cases have identified several neurotoxicants, including MPP (+) (the active metabolite of MPTP), paraquat, dieldrin, manganese and salsolinol.
Finally, the high throughput cDNA microarray screening using the current model identified downstream response genes, such as heme oxygenase-1, a constituent of Lewy bodies, that can be the useful biomarkers to monitor the pathological conditions of dopaminergic neurons under neurotoxic insult.
1(0,0,0,1) Details