Protein Information

Name neurotrophic factors
Synonyms ARTN; Artemin; Artemin precursor; EVN; Enovin; NBN; Neublastin; Neuroblastin…

Compound Information

Name dieldrin
CAS

Reference List

PubMed Abstract RScore(About this table)
19130878 Slotkin TA, Seidler FJ, Fumagalli F: Unrelated developmental neurotoxicants elicit similar transcriptional profiles for effects on neurotrophic factors and their receptors in an in vitro model. Neurotoxicol Teratol. 2010 Jan-Feb;32(1):42-51. Epub 2008 Dec 13.

We examined an organophosphate pesticide (diazinon), an organochlorine pesticide (dieldrin) and a metal (Ni (2+)) for effects on the expression of neurotrophic factors and their receptors and modulators in differentiating PC12 cells, an in vitro model of neuronal development.
32(0,1,1,2) Details
19368821 Slotkin TA, Seidler FJ: Protein kinase C is a target for diverse developmental neurotoxicants: transcriptional responses to chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells. Brain Res. 2009 Mar 31;1263:23-32. Epub 2009 Feb 5.

We compared two organophosphate insecticides (chlorpyrifos, diazinon) with an organochlorine (dieldrin) and a metal (Ni (2+)) for similarities and differences in their effects on gene expression encoding subtypes of protein kinase C and their modulators, a cell signaling cascade that integrates the actions of neurotrophic factors involved in brain development.
6(0,0,1,1) Details