| Name | protein kinase C (protein family or complex) |
|---|---|
| Synonyms | Protein kinase C; PKC |
| Name | dieldrin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19368821 | Slotkin TA, Seidler FJ: Protein kinase C is a target for diverse developmental neurotoxicants: transcriptional responses to chlorpyrifos, diazinon, dieldrin and divalent in PC12 cells. Brain Res. 2009 Mar 31;1263:23-32. Epub 2009 Feb 5. |
87(1,1,2,2) | Details |
| 8470122 | Newsted JL, Giesy JP: Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the epidermal growth factor receptor in hepatic plasma membranes of rainbow trout (Oncorhynchus mykiss). Toxicol Appl Pharmacol. 1993 Mar;119(1):41-51. Protein kinase C and kinase activity as well as EGF-receptor phosphorylation was greater in livers of treated fish than in those of control fish within 5 days but returned to control levels by 40 days postinjection. |
4(0,0,0,4) | Details |
| 2920298 | Aylsworth CF, Trosko JE, Chang CC, Benjamin K, Lockwood E: Synergistic inhibition of metabolic cooperation by or 12-0-tetradecanoylphorbol-13- and dichlorodiphenyltrichlorethane (DDT) in Chinese hamster V79 cells: implication of a role for protein kinase C in the regulation of gap junctional intercellular communication. Cell Biol Toxicol. 1989 Jan;5(1):27-37. |
2(0,0,0,2) | Details |
| 7690584 | Carrero I, Rodriguez-Henche N, Guijarro LG, Recio MN, Perez-Albarsanz MA, Prieto JC: Lindane decreases forskolin-stimulated cyclic AMP accumulation but does not modify Gs in rat enterocytes. Cell Signal. 1993 Jul;5(4):453-62. There was a certain degree of specificity since delta-HCCH was indeed more potent, whereas dieldrin and endrin (non-lindane related halogenated compounds) behaved as lindane, and alpha- and beta-HCCH were poorly efficient on the inhibition of forskolin stimulation of adenylate cyclase activity. The results on a non-receptor mediated effect of lindane on the adenylate cyclase catalytic subunit itself could be related to: (i) alterations of membrane microdomains surrounding this and other integral proteins which would result in modifications of their activities; and/or (ii) a reciprocal relation between the two main routes of signal transduction so that the activation of protein kinase C (or other Ca (2+)-dependent protein kinases) by lindane would lead to phosphorylation of the adenylate cyclase catalytic subunit.(ABSTRACT TRUNCATED AT 250 WORDS) |
1(0,0,0,1) | Details |
| 2467674 | Carrero I, Fernandez-Moreno MD, Perez-Albarsanz MA, Prieto JC: Lindane effect upon the vasoactive intestinal peptide receptor/effector system in rat enterocytes. Biochem Biophys Res Commun. 1989 Mar 31;159(3):1391-6. Lindane action exhibited an important degree of specificity since the isomer alpha-HCCH and endrin reproduced the same inhibitory pattern but beta-HCCH and dieldrin were inactive. Among various possibilities, the results suggest the modification of membrane fluidity by lindane and/or the activation of Ca2+-dependent protein kinase C by this compound leading to phosphorylation of Gs/adenylate cyclase. |
1(0,0,0,1) | Details |
| 11485862 | Buznikov GA, Nikitina LA, Bezuglov VV, Lauder JM, Padilla S, Slotkin TA: An invertebrate model of the developmental neurotoxicity of insecticides: effects of chlorpyrifos and dieldrin in sea urchin embryos and larvae. Environ Health Perspect. 2001 Jul;109(7):651-61. Studies with cholinergic receptor blocking agents and protein kinase C inhibitors indicated two distinct types of effects, one mediated through stimulation of nicotinic cholinergic receptors and the other targeting intracellular signaling. |
1(0,0,0,1) | Details |
| 10397453 | Ohmori K, Miyazaki K, Umeda M: Detection of tumor promoters by early antigen expression of EB virus in Raji cells using a fluorescence microplate-reader. Cancer Lett. 1998 Oct 23;132(1-2):51-9. EBV-EA induction by TPA was related to the activation of protein kinase C and phospholipase A2. The chemicals that reacted positively were okadaic acid, diethylstilbestrol, phenobarbital, aldrin and dieldrin. |
1(0,0,0,1) | Details |