Protein Information

Name cytosolic epoxide hydrolase
Synonyms CEH; Epoxide hydratase; Cytosolic epoxide hydrolase; EPHX 2; EPHX2; Epoxide hydrolase 2; SEH; Soluble epoxide hydrolase…

Compound Information

Name dieldrin
CAS

Reference List

PubMed Abstract RScore(About this table)
2043152 Moody DE, Montgomery KA, Ashour MB, Hammock BD: Effects of environmentally encountered epoxides on mouse liver epoxide-metabolizing enzymes. Biochem Pharmacol. 1991 Jun 1;41(11):1625-37.

Male mice were treated (i.p.) for 3 days with 15 different environmentally encountered epoxides, and the effects of these compounds on liver microsomal and cytosolic epoxide hydrolase (mEH and cEH), glutathione S-transferase (mGST and cGST) and carboxylesterase (mCE) activities were determined.
The epoxides included the pesticides: heptachlor epoxide, dieldrin, tridiphane, and juvenoid R-20458; the natural products: disparlure, limonin, nomilin, and epoxymethyloleate; the endogenous steroids: lanosterol epoxide, cholesterol-alpha-epoxide, and progesterone epoxide; and the industrial or synthetic epoxides: epichlorohydrin, araldite, trans-stilbene oxide, and 4'-phenylchalcone oxide.
1(0,0,0,1) Details
12883087 Barnhill ML, Rosemond MV, Curtis LR: Dieldrin stimulates biliary excretion of 14C-benzo [a] pyrene polar metabolites but does not change the biliary metabolite profile in rainbow trout (Oncorhyncus mykiss). Toxicol Sci. 2003 Oct;75(2):249-59. Epub 2003 Jul 25.

Activities of hepatic microsomal and cytosolic epoxide hydrolases, accumulation of dieldrin in liver, and in vivo metabolism and disposition of the polycyclic aromatic hydrocarbon (PAH), benzo [a] pyrene (BP), were examined in rainbow trout pretreated with dieldrin, a chlorinated cyclodiene insecticide.
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638200 Walker CH, Bentley P, Oesch F: Phylogenetic distribution of epoxide hydratase in different vertebrate species, strains and tissues measured using three substrates. Biochim Biophys Acta. 1978 Apr 3;539(4):427-34.

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