Protein Information

Name CTR1
Synonyms CALCR; CTR 1; CTR1; CRT; CT R; CTR; Calcitonin receptor; Calcitonin receptor precursor…

Compound Information

Name sulfur
CAS sulfur

Reference List

PubMed Abstract RScore(About this table)
20159940 Howell SB, Safaei R, Larson CA, Sailor MJ: Copper transporters and the cellular pharmacology of the platinum-containing cancer drugs. Mol Pharmacol. 2010 Feb 16.

Cu and Pt (II) have similar sulfur binding characteristics and the presence of stacked rings of methionines and cysteines in the CTR1 trimer suggest a mechanism by which CTR1 selectively transports Cu and the Pt-containing drugs via sequential transchelation reactions similar to the manner in which Cu is passed from ATOX1 to the Cu efflux transporters.
86(1,1,1,6) Details
19731715 Cusick KD, Boyer GL, Wilhelm SW, Sayler GS: Transcriptional profiling of Saccharomyces cerevisiae upon exposure to saxitoxin. Environ Sci Technol. 2009 Aug 1;43(15):6039-45.


In general, the genes encoding the metallothioneins CUP1 and CRS5 were induced following exposure to saxitoxin, while those encoding the ferric/ cupric reductase FRE1 and the copper uptake transporter CTR1 were repressed.
1(0,0,0,1) Details