Protein Information

Name cholinesterase
Synonyms Acylcholine acylhydrolase; BCHE; BCHE protein; Butyrylcholine esterase; Butyrylcholinesterase; CHE1; Choline esterase II; Cholinesterase…

Compound Information

Name bromophos
CAS

Reference List

PubMed Abstract RScore(About this table)
3341046 Shivanandappa T, Joseph P, Krishnakumari MK: Response of blood and brain cholinesterase to dermal exposure of bromophos in the rat. Toxicology. 1988 Feb;48(2):199-208.

In a subacute study, daily dermal application of 50 mg/kg body weight of Bromophos for 5 and 10 days, resulted in high inhibition of the serum cholinesterase and brain acetylcholinesterase, the former being more marked which was reversible after 10 or 15 days of post-exposure period.
132(1,2,5,7) Details
4715482 Muacevic G: Acute toxicity and cholinesterase inhibition in vivo of bromophos-ethyl. Toxicol Appl Pharmacol. 1973 Jun;25(2):180-9.
81(1,1,1,1) Details
8481105 Willems JL, De Bisschop HC, Verstraete AG, Declerck C, Christiaens Y, Vanscheeuwyck P, Buylaert WA, Vogelaers D, Colardyn F: Cholinesterase reactivation in organophosphorus poisoned patients depends on the plasma concentrations of the oxime pralidoxime methylsulphate and of the organophosphate. Arch Toxicol. 1993;67(2):79-84.

The bromophos poisoning was rather mild, cholinesterases were moderately inhibited and increased under oxime therapy.
38(0,1,2,3) Details
7935256 Santhoshkumar P, Shivanandappa T: Differential in vivo inhibition of the foetal and maternal brain acetylcholinesterase by bromophos in the rat. Neurotoxicol Teratol. 1994 May-Jun;16(3):227-32.

This study measured the in vivo time-course of cholinesterase (ChE) inhibition and recovery in rat maternal serum, brain, and foetal brain after administration of a single acute oral dose of Bromophos (500 mg/kg b.w.) on Day 18 of pregnancy.
31(0,1,1,1) Details
212825 Stalberg E, Hilton-Brown P, Kolmodin-Hedman B, Holmstedt B, Augustinsson KB: Effect of occupational exposure to organophosphorus insecticides on neuromuscular function. Scand J Work Environ Health. 1978 Sep;4(3):255-61.

Neurophysiological investigations and determinations of cholinesterase activity on plasma and erythrocytes were carried out on 11 Swedish spraymen exposed to bromophos, diazinon, dursbane, and malathion.
8(0,0,1,3) Details
5422207 Muacevic G, Dirks E, Kinkel HJ, Leuschner F: Anticholinesterase activity of bromophos in rats and dogs. Toxicol Appl Pharmacol. 1970 May;16(3):585-96.
6(0,0,1,1) Details
52151 Ramisz A, Komorowski A: [Histochemical study of the effect of phosphoroorganic esters Z-50 (fenchlorfos) and Z-51 (bromophos) on cholinesteras activity in the course of the muscle phase in experimental trichinellosis in mice]. Pol Arch Weter. 1975;17(4):623-31.

The influence of esters on the activity of cholinesterases was investigated with the Koelle-Friedenwald method, modified by Gomori.
4(0,0,0,4) Details
8812210 Santhoshkumar P, Karanth S, Shivanandappa T: Neurotoxicity and pattern of acetylcholinesterase inhibition in the brain regions of rat by bromophos and ethylbromophos. Fundam Appl Toxicol. 1996 Jul;32(1):23-30.

In vivo cholinesterase inhibition was in the order plasma > erythrocytes > brain.
2(0,0,0,2) Details
8727219 Nagayama M, Akahori F, Chiwata H, Shirai M, Motoya M, Masaoka T, Sakaguchi K: Effects of selected organophosphate insecticides on serum cholinesterase isoenzyme patterns in the rat. Vet Hum Toxicol. 1996 Jun;38(3):196-9.

The effects of organophosphates (fenthion, chlorpyrifos, diazinon, bromophos, propaphos, haloxon, and DFP) on serum ChE isoenzyme bands were studied in 32 male and 32 female 6-w-old Sprague-Dawley rats.
2(0,0,0,2) Details
985225 Stone BF, Wilson JT, Youlton NJ: Linkage and dominance characteristics of genes for resistance to organophosphorus acaricides and allelic inheritance of decreased brain cholinesterase activity in three strains of the cattle tick, Boophilus microplus. Aust J Biol Sci. 1976 Jul;29(3):251-63.

No F1 larval progeny from the following crossings were appreciably more resistant than their parents to these chemicals: R x B--bromophos ethyl and fenthion; B x M--carbaryl, chlorfenvinphos, chlorpyrifos, diazinon, dimethoate, ethion, fenthion and formothion; M x R--chlorfenvinphos, diazinon, dimethoate, ethion, formothion.
1(0,0,0,1) Details
2051507 Koppel C, Thomsen T, Heinemeyer G, Roots I: Acute poisoning with bromofosmethyl (bromophos). . J Toxicol Clin Toxicol. 1991;29(2):203-7.

In contrast to poisoning by most organophosphates, red blood cell acetyl cholinesterase was only minimally depressed but the plasma butyryl cholinesterase was initially decreased and normalized within a few days.
1(0,0,0,1) Details
10557009 Guven M, Bayram F, Unluhizarci K, Kelestimur F: Endocrine changes in patients with acute organophosphate poisoning. Hum Exp Toxicol. 1999 Oct;18(10):598-601.


In animals, cholinesterase inhibitors were shown to modify the pituitary-thyroid and pituitary-adrenal axes, and to affect prolactin levels.
1(0,0,0,1) Details