Protein Information

Name lactate dehydrogenase (protein family or complex)
Synonyms LDH; lactate dehydrogenase; lactate dehydrogenases

Compound Information

Name carbaryl
CAS

Reference List

PubMed Abstract RScore(About this table)
6092205 Parafita MA, Fernandez-Otero P: The interaction of carbaryl with the metabolism of isolated hepatocytes: II. Gen Pharmacol. 1984;15(4):333-7.

The effects of 1-naphthyl-N-methylcarbamate (carbaryl) upon glucose production from several precursors (lactate, glycerol, alanine, fructose and pyruvate) and on activities of gluconeogenic enzymes (glucose-6-phosphatase, lactate dehydrogenase and aspartate aminotransferase) in isolated rat hepatocytes was studied.
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10478330 Sharma B: Effect of carbaryl on some biochemical constituents of the blood and liver of Clarias batrachus, a fresh-water teleost. J Toxicol Sci. 1999 Aug;24(3):157-64.

The treatment of the fish with carbaryl led to a marked increase in the activities of transaminases (GOT and GPT), phosphatases (acid and alkaline) and lactate dehydrogenase in the fish serum, the magnitude of the effect being dependent on the pesticide concentration and duration of exposure.
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1830481 Reddy MS, Rao KV: Tissue glycolytic potentials of penaeid prawn, Metapenaeus monoceros during methylparathion, carbaryl and aldrin exposure. Biochem Int. 1991 Jan;23(2):367-75.

The decrease in the lactate dehydrogenase activity levels and an increase in the lactate content indicative of reduced mobilization of pyruvate into the citric acid cycle.
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8592826 Pant N, Srivastava SC, Prasad AK, Shankar R, Srivastava SP: Effects of carbaryl on the rat's male reproductive system. . Vet Hum Toxicol. 1995 Oct;37(5):421-5.

Testicular enzymes associated with post-meiotic spermatogenic cells (sorbitol dehydrogenase) decreased, while lactate dehydrogenase increased concomitant with the observed degeneration of spermatogenic cells.
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6818721 Sastry KV, Siddiqui AA: Chronic toxic effects of the carbamate pesticide sevin on carbohydrate metabolism in a freshwater snakehead fish, Channa punctatus. Toxicol Lett. 1982 Nov;14(1-2):123-30.


In liver, muscles, brain and gills the lactate dehydrogenase (LDH) activity was higher in pesticide-exposed fish in comparison to control fish, but the same enzyme activity was inhibited in kidney and intestine.
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9720142 Dong W, Gilmour MI, Lambert AL, Selgrade MK: Enhanced allergic responses to house dust mite by oral exposure to carbaryl in rats. Toxicol Sci. 1998 Jul;44(1):63-9.

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