Protein Information

Name beta glucuronidase
Synonyms Beta glucuronidase; Beta G1; Beta glucuronidase precursor; GUSB; MPS 7; MPS7; Beta G1s; Beta glucuronidase precursors

Compound Information

Name carbaryl
CAS

Reference List

PubMed Abstract RScore(About this table)
120242 Chen KC, Dorough HW: Glutathione and mercapturic acid conjugations in the metabolism of naphthalene and 1-naphthyl N-methylcarbamate (carbaryl). Drug Chem Toxicol. 1979;2(4):331-54.

With the aid of the specific enzyme (e.g. beta-glucuronidase and sulfatase) and acid hydrolysis, the water-soluble metabolites of [naphthyl-14C]-carbaryl were tentatively recognized as glucuronide or sulfate conjugated mainly with 5,6-dihydro-5,6-dihydroxycarbaryl or N-hydroxy-methyl carbaryl and their hydrolytic products.
81(1,1,1,1) Details
7265327 Kikuchi H, Suzuki Y, Hashimoto Y: Increase of beta-glucuronidase activity in the serum of rats administered organophosphate and carbamate insecticides. J Toxicol Sci. 1981 Feb;6(1):27-35.

An approximately 50-fold increase in serum beta-glucuronidase activity appeared 2 hours after the administration of such organophosphate insecticides as dichlorvs, diazinon and disulfoton and of a carbamate insecticide, carbaryl.
8(0,0,1,3) Details
10421485 Satoh T, Suzuki S, Kawai N, Nakamura T, Hosokawa M: Toxicological significance in the cleavage of esterase-beta-glucuronidase complex in liver microsomes by organophosphorus compounds. Chem Biol Interact. 1999 May 14;119-120:471-8.

Similarly, carbamate insecticides such as carbaryl caused rapid increase of plasma beta-G level.
3(0,0,0,3) Details
12856628 Ichinoki S, Takido N, Fujii Y, Morita T, Ieiri I, Otsubo K, Saitoh N: [Simultaneous determination of carbaryl and propanil in human serum and urine by on-line column-switching technique followed by automatic reversed-phase HPLC]. Chudoku Kenkyu. 2003 Apr;16(2):171-8.

Urine was incubated with beta-glucuronidase/arylsulfate for 16 hours at 37 degrees C.
1(0,0,0,1) Details