| Name | CYP1A1 |
|---|---|
| Synonyms | AHH; AHRR; Arylhydrocarbon hydroxylase; CP11; CYP 1; CYP1; CYP1A1; CYPIA 1… |
| Name | carbaryl |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9853009 | Denison MS, Phelan D, Winter GM, Ziccardi MH: Carbaryl, a insecticide, is a ligand for the hepatic Ah (dioxin) receptor. Toxicol Appl Pharmacol. 1998 Oct;152(2):406-14. Induction of CYP1A1 gene expression is one such response that is known to be regulated by the AhR complex. |
1(0,0,0,1) | Details |
| 17193320 | Schmidt B, Faymonville T, Gembe E, Joussen N, Schuphan I: Comparison of the biotransformation of the 14C-labelled insecticide carbaryl by non-transformed and human CYP1A1-, CYP1A2-, and CYP3A4-transgenic cell cultures of Nicotiana tabacum. Chem Biodivers. 2006 Aug;3(8):878-96. A rapid conversion rate of carbaryl was observed with the CYP1A1 and CYP1A2 cells, where only 49.7 and 0.2% of applied carbaryl (1 mg/l), respectively, remained after 24 h, as compared to 77.7% in the non-transformed culture. |
94(1,1,3,4) | Details |
| 11226373 | Delescluse C, Ledirac N, Li R, Piechocki MP, Hines RN, Gidrol X, Rahmani R: Induction of cytochrome P450 1A1 gene expression, oxidative stress, and genotoxicity by carbaryl and thiabendazole in transfected human HepG2 and lymphoblastoid cells. Biochem Pharmacol. 2001 Feb 15;61(4):399-407. Carbaryl and thiabendazole were found to activate CYP1A1 at the level of transcription, as demonstrated by the dose-dependent increase in reporter CAT and CYP1A1 mRNAs. |
89(1,1,2,4) | Details |
| 10620349 | Sandoz C, Lesca P, Narbonne JF, Carpy A: Molecular characteristics of carbaryl, a CYP1A1 gene inducer. Arch Biochem Biophys. 2000 Jan 1;373(1):275-80. Carbaryl belongs to a series of compounds that activate the CYP1A1 gene. |
87(1,1,2,2) | Details |
| 9858662 | Sandoz C, Lesca P, Carpy A, Laguionie M, Narbonne JF: Effects of carbaryl and naphthalene on rat hepatic CYP1A1/2: potential binding to Ah receptor and 4S benzo (a) pyrene-binding protein. Int J Mol Med. 1998 Nov;2(5):615-23. |
63(0,2,2,3) | Details |
| 9169082 | Ledirac N, Delescluse C, de Sousa G, Pralavorio M, Lesca P, Amichot M, Berge JB, Rahmani R: Carbaryl induces CYP1A1 gene expression in HepG2 and HaCaT cells but is not a ligand of the human hepatic Ah receptor. Toxicol Appl Pharmacol. 1997 May;144(1):177-82. Studies on HepG2 and HaCaT cell lines showed that carbaryl is capable of increasing, in a dose-dependent manner, both the ethoxyresorufin rufin-O-dec, O-deethylase activity and the steady-state concentrations of CYP1A1 mRNA, suggesting a transcriptional activation of this gene. |
39(0,1,2,4) | Details |
| 19356113 | Breuer MA, Schmidt B, Schuphan I: Utility of Nicotiana tabacum cell suspension cultures expressing human CYP1A1, CYP1A2 and CYP3A4 to study the oxidative metabolism of the herbicide 14C-fluometuron. Drug Metab Lett. 2009 Jan;3(1):18-27. Experimental parameters modified were concentration of (14) C-fluometuron, incubation period, and additional application of inhibitor carbaryl. |
4(0,0,0,4) | Details |
| 9820645 | Delescluse C, Ledirac N, de Sousa G, Pralavorio M, Lesca P, Rahmani R: Cytotoxic effects and induction of cytochromes P450 1A1/2 by insecticides, in hepatic or epidermal cells: binding capability to the Ah receptor. Toxicol Lett. 1998 Aug;96-97:33-9. We therefore tested the comparative acute and chronic toxicity of chemicals belonging to the major insecticides families (DDT, malathion and tetrachlorvinphos, carbaryl, cypermethrin, diflubenzuron), in hepatocytes, HepG2 and HaCaT cell lines. Two kinds of end-points were used: cytotoxicity parameters and CYP1A1 induction. |
1(0,0,0,1) | Details |
| 12385721 | Tang J, Cao Y, Rose RL, Hodgson E: In vitro metabolism of carbaryl by human cytochrome P450 and its inhibition by chlorpyrifos. Chem Biol Interact. 2002 Oct 20;141(3):229-41. CYP1A1 and 1A2 had the greatest ability to form 5-hydroxycarbaryl, while CYP3A4 and CYP1A1 were the most active in generation of 4-hydroxycarbaryl. |
1(0,0,0,1) | Details |