| Name | caspase 3 |
|---|---|
| Synonyms | Apopain; CASP 3; CASP3; CPP 32; CPP32; CPP32B; Caspase 3; Caspase 3 precursor… |
| Name | dichlorvos |
|---|---|
| CAS | 2,2-dichloroethenyl dimethyl phosphate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17850875 | Kaur P, Radotra B, Minz RW, Gill KD: Impaired mitochondrial energy metabolism and neuronal apoptotic cell death after chronic dichlorvos (OP) exposure in rat brain. Neurotoxicology. 2007 Nov;28(6):1208-19. Epub 2007 Aug 7. Thus, chronic organophosphate exposure has the potential to disrupt cellular antioxidant defense system which in turn triggers the release of cytochrome c from mitochondria to cytosol as well as caspase-3 activation in dichlorvos treated rat brain as revealed by immunoblotting experiments. |
81(1,1,1,1) | Details |
| 14568351 | Pena-Llopis S, Ferrando MD, Pena JB: Fish tolerance to organophosphate-induced oxidative stress is dependent on the glutathione metabolism and enhanced by Aquat Toxicol. 2003 Dec 10;65(4):337-60. The present work studied the effects of the antioxidant and pro-drug N-acetyl- (NAC) on the survival of a natural population of A. anguilla exposed to a lethal concentration of dichlorvos, focusing on the glutathione metabolism and the enzyme activities of acetylcholinesterase (AChE) and caspase-3 as biomarkers of neurotoxicity and induction of apoptosis, respectively. |
7(0,0,1,2) | Details |
| 20218312 | Zeng L, Wang YY, Zhang J, Lin P, Gong XD, Huang LG: [In utero exposure to dichlorvos induces apoptosis of Leydig cells in rats]. Zhonghua Nan Ke Xue. 2009 Nov;15(11):1001-6. After birth, 5 male neonates were randomly selected from each of the control and dichlorvos groups, and their testes were harvested to be analyzed by HE staining, immunohistochemistry with anti-caspase-3 antibodies and DAPI fluorescent staining. |
6(0,0,1,1) | Details |
| 17681413 | Li Q, Kobayashi M, Kawada T: Organophosphorus pesticides induce apoptosis in human NK cells. Toxicology. 2007 Sep 24;239(1-2):89-95. Epub 2007 Jul 5. NK-92CI and/or NK-92MI were treated with dichlorvos (DDVP) or chlorpyrifos (CP) at 0-100 ppm for 1-72 h at 37 degrees C in vitro. Apoptosis induced by DDVP and CP was determined by FITC-Annexin V staining and the intracellular level of active caspase-3 was analysed by flow cytometry. |
2(0,0,0,2) | Details |
| 16973328 | Oral B, Guney M, Demirin H, Ozguner M, Giray SG, Take G, Mungan T, Altuntas I: Endometrial damage and apoptosis in rats induced by dichlorvos and ameliorating effect of antioxidant vitamins E and C. Reprod Toxicol. 2006 Nov;22(4):783-90. Epub 2006 Aug 18. Histopathological and immunohistochemical examinations for caspase-3 and caspase-9 were accomplished in the endometrium. |
1(0,0,0,1) | Details |
| 19631781 | Liu CY, Chang PA, Wu YJ: Trichlorfon induces apoptosis in SH-SY5Y neuroblastoma cells via the endoplasmic reticulum?. Chem Biol Interact. 2009 Sep 14;181(1):37-44. Epub 2009 Mar 20. Flow cytometric analysis demonstrated that trichlorfon and its degradation product dichlorvos-induced apoptosis in a dose-dependent manner and Hoechst 33342 staining experiments revealed trichlorfon/dichlorvos-induced nucleus condensation. Percent apoptosis and activated caspase-3 and caspase-12 decreased in pre-treated cells compared to those treated with trichlorfon alone. |
1(0,0,0,1) | Details |