Protein Information

Name hemoglobin (protein family or complex)
Synonyms Hemoglobin; Hemoglobins

Compound Information

Name chlorpropham
CAS

Reference List

PubMed Abstract RScore(About this table)
10942323 Fujitani T, Tada Y, Fujii A, Kimura M, Yoneyama M: Subchronic toxicity of chlorpropham (CIPC) in ICR mice. Food Chem Toxicol. 2000 Jul;38(7):617-25.

Hemoglobin concentration, packed cell volume, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration and white blood cell count of male and female mice in the 30,000 ppm group were significantly increased.
1(0,0,0,1) Details
2295119 Sabbioni G, Neumann HG: Biomonitoring of arylamines: hemoglobin adducts of urea and carbamate pesticides. Carcinogenesis. 1990 Jan;11(1):111-5.

The following binding indices [HBI, hemoglobin binding index = binding (mmol/mol Hb) per dose (mmol/kg)] were obtained: pesticide (arylamine): linuron, diuron (3,4-dichloroaniline) 0.8 and 4.5 respectively; monuron, monolinuron (4-chloroaniline) 39 and 55 respectively; chlorpropham (3-chloroaniline) 2.9; chlordimeform (4-chloro-o-toluidine) 2.4; propham (aniline) 2.4.
35(0,1,1,5) Details
11278057 Fujitani T, Tada Y, Noguchi AT, Yoneyama M: Effects of chlorpropham (CIPC) on the hemopoietic system of rats. Food Chem Toxicol. 2001 Mar;39(3):253-9.

The covalent binding of m-chloraniline m-CA, (the hydrolytic metabolite of chlorpropham) was observed in hemoglobin or splenic protein of treated rats, but only small amounts of free m-CA were present in blood or spleen.
32(0,1,1,2) Details
9347926 Fujitani T, Tada Y, Noguchi AT, Yoneyama M: Hemotoxicity of chlorpropham (CIPC) in F344 rats. Toxicology. 1997 Nov 21;123(1-2):111-24.

Red blood cell count, hemoglobin concentration, hematocrit, mean corpuscular hemoglobin concentration and platelet count were decreased in male and female rats of the treated groups.
2(0,0,0,2) Details