Protein Information

Name thioredoxin like
Synonyms 32 kDa thioredoxin related protein; TRP32; TXL; TXL 1; TXL1; TXNL; TXNL 1; TXNL1…

Compound Information

Name sulfur
CAS sulfur

Reference List

PubMed Abstract RScore(About this table)
19722697 Liu Y, Cowan JA: Iron-sulfur cluster biosynthesis: characterization of a molten globule domain in human NFU. Biochemistry. 2009 Aug 11;48(31):7512-8.

This C-terminal domain contains a pair of redox active cysteines and demonstrates thioredoxin-like activity by both binding to and mediating persulfide bond cleavage of sulfur-loaded IscS, the sulfide donor for [2Fe-2S] cluster assembly on ISU-type scaffold proteins.
81(1,1,1,1) Details
20306235 Hawkes WC, Alkan Z: Regulation of Redox Signaling by Selenoproteins. Biol Trace Elem Res. 2010 Mar 20.

Recent evidence suggests selenoprotein W and the six other small thioredoxin-like mammalian selenoproteins may serve to transduce hydrogen peroxide signals into regulatory disulfide bonds in specific target proteins.
The sulfur amino acids, cysteine and methionine, are the main targets of reactive oxygen species in proteins.
1(0,0,0,1) Details