| Name | flavin containing monooxygenase 1 |
|---|---|
| Synonyms | Dimethylaniline monooxygenase 1; Dimethylaniline monooxygenase [N oxide forming] 1; Dimethylaniline oxidase 1; FMO 1; FMO1; Fetal hepatic flavin containing monooxygenase 1; Flavin containing monooxygenase 1; Dimethylaniline monooxygenase [N oxide forming] 1s… |
| Name | fenthion |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 14976351 | Furnes B, Schlenk D: Evaluation of xenobiotic N- and S-oxidation by variant flavin-containing monooxygenase 1 (FMO1) enzymes. Toxicol Sci. 2004 Apr;78(2):196-203. Epub 2004 Feb 19. FMO1 also metabolized the commonly used insecticide fenthion to its (+)-sulfoxide, with relatively high catalytic efficiency. |
120(1,2,2,10) | Details |
| 17253727 | Gadepalli RS, Rimoldi JM, Fronczek FR, Nillos M, Gan J, Deng X, Rodriguez-Fuentes G, Schlenk D: Synthesis of fenthion sulfoxide and fenoxon sulfoxide enantiomers: effect of chirality on acetylcholinesterase activity. Chem Res Toxicol. 2007 Feb;20(2):257-62. Epub 2007 Jan 25. Earlier reports have demonstrated that recombinant flavin-containing monooxygenase 1 (FMO1) catalyzes the oxidation of the organophosphate pesticide fenthion to (+)-fenthion sulfoxide in a stereoselective fashion. |
112(1,2,2,2) | Details |
| 15547051 | Furnes B, Schlenk D: Extrahepatic metabolism of and organophosphate thioether compounds by the flavin-containing monooxygenase and cytochrome P450 systems. Drug Metab Dispos. 2005 Feb;33(2):214-8. Epub 2004 Nov 16. The relative contribution of FMO1 and FMO3 to the sulfoxidation of carbophenothion, demeton-O, ethiofencarb, fonofos, and methiocarb also was investigated by using baculovirus-expressed recombinant proteins. Stereoselective sulfoxidation of fenthion and methiocarb by human liver, kidney, and microsomes was investigated. |
3(0,0,0,3) | Details |
| 12527698 | Kitamura S, Suzuki T, Kadota T, Yoshida M, Ohashi K, Ohta S: In vitro metabolism of fenthion and fenthion sulfoxide by liver preparations of sea bream, goldfish, and rats. Drug Metab Dispos. 2003 Feb;31(2):179-86. Several cytochrome P450 isoforms and flavin-containing monooxygenase 1 exhibited these oxidase activities. |
1(0,0,0,1) | Details |