Protein Information

Name steroidogenic acute regulatory protein
Synonyms Cholesterol trafficker; STAR; STARD 1; STARD1; Start domain containing protein 1; Steroidogenic acute regulator; Steroidogenic acute regulatory protein; Start domain containing protein 1s…

Compound Information

Name fenvalerate
CAS cyano(3-phenoxyphenyl)methyl 4-chloro-α-(1-methylethyl)benzeneacetate

Reference List

PubMed Abstract RScore(About this table)
18053657 Qu JH, Hong X, Chen JF, Wang YB, Sun H, Xu XL, Song L, Wang SL, Wang XR: Fenvalerate inhibits progesterone production through cAMP-dependent signal pathway. Toxicol Lett. 2008 Jan 4;176(1):31-9. Epub 2007 Sep 21.

In addition, fenvalerate decreased steroidogenic acute regulatory protein (StAR) mRNA and protein levels, and also profoundly inhibited the activity of P450 side chain cleavage enzyme (P450scc) which was consistent with the decreased expression of P450scc mRNA and protein in MLTC-1 cells.
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19892000 Fei J, Qu JH, Ding XL, Xue K, Lu CC, Chen JF, Song L, Xia YK, Wang SL, Wang XR: Fenvalerate inhibits the growth of primary cultured rat preantral ovarian follicles. Toxicology. 2010 Jan 12;267(1-3):1-6. Epub 2009 Nov 3.

And then the morphous was assessed by conventional light microscopy, steroid hormones were measured by RIA, and the expressions of steroidogenic acute regulatory protein (StAR) and cytochrome P450 side-chain cleavage enzyme (P450scc) were monitored by real-time quantitative PCR analysis.
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15907653 Chen J, Chen H, Liu R, He J, Song L, Bian Q, Xu L, Zhou J, Xiao H, Dai G, Chang HC, Wang X: Effects of fenvalerate on progesterone production in cultured rat granulosa cells. Reprod Toxicol. 2005 Jul-Aug;20(2):195-202.

Expression of P450 side chain cleavage enzyme (P450scc) and steroidogenic acute regulatory protein (StAR) were monitored by real-time PCR and Western blotting.
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