| Name | ferrochelatase |
|---|---|
| Synonyms | EPP; FCE; FECH; Ferrochelatase; Ferrochelatase (protoporphyria); Heme synthase; Heme synthetase; Iron chelatase… |
| Name | sulfur |
|---|---|
| CAS | sulfur |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19805308 | Huang ML, Becker EM, Whitnall M, Rahmanto YS, Ponka P, Richardson DR: Elucidation of the mechanism of mitochondrial iron loading in Friedreich's ataxia by analysis of a mouse mutant. Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16381-6. Epub 2009 Sep 4. Using cardiac tissues, we demonstrate that frataxin deficiency leads to down-regulation of key molecules involved in 3 mitochondrial utilization pathways: iron-sulfur cluster (ISC) synthesis (iron-sulfur cluster scaffold protein1/2 and the desulferase Nfs1), mitochondrial iron storage (mitochondrial ferritin), and heme synthesis dehydratase, coproporphyrinogen oxidase, hydroxymethylbilane synthase, uroporphyrinogen III synthase, and ferrochelatase). |
31(0,1,1,1) | Details |
| 19965627 | Crooks DR, Ghosh MC, Haller RG, Tong WH, Rouault TA: Posttranslational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability and intact iron-sulfur cluster assembly machinery. Blood. 2010 Jan 28;115(4):860-9. Epub 2009 Nov 25. Mammalian ferrochelatase, the terminal enzyme in the heme biosynthetic pathway, possesses an iron-sulfur [2Fe-2S] cluster that does not participate in catalysis. |
7(0,0,0,7) | Details |
| 20138927 | Wu S, Huang R, Xu L, Yan G, Wang Q: Improved production with expression of hemH and lba genes in chloroplast of Chlamydomonas reinhardtii. J Biotechnol. 2010 Apr 1;146(3):120-5. Epub 2010 Feb 6. The coding region of both the ferrochelatase gene, hemH, from Bradyrhizobium japonicum, and the leghemoglobin gene, lba, from max, were transferred into chloroplast of Chlamydomonas reinhardtii. As a result, transgenic C. reinhardtii cultures more rapidly consumed O (2) and increased H (2) output compared with controls in both sulfur-free and sulfur-containing medium. |
1(0,0,0,1) | Details |
| 19460301 | Seguin A, Bayot A, Dancis A, Rogowska-Wrzesinska A, Auchere F, Camadro JM, Bulteau AL, Lesuisse E: Overexpression of the yeast frataxin homolog (Yfh1): contrasting effects on iron-sulfur cluster assembly, heme synthesis and resistance to oxidative stress. Mitochondrion. 2009 Apr;9(2):130-8. Epub 2009 Jan 22. By contrast, endogenous mitochondrial iron was more available to ferrochelatase in 2muYFH1 cells than in wild-type cells, resulting in higher levels of heme synthesis in vitro. |
1(0,0,0,1) | Details |