Protein Information

Name glycine receptor (protein family or complex)
Synonyms Glycine receptor; Glycine receptors

Compound Information

Name fipronil
CAS

Reference List

PubMed Abstract RScore(About this table)
16611622 Stehr CM, Linbo TL, Incardona JP, Scholz NL: The developmental neurotoxicity of fipronil: notochord degeneration and locomotor defects in zebrafish embryos and larvae. Toxicol Sci. 2006 Jul;92(1):270-8. Epub 2006 Apr 12.

Although specifically developed to target insect GABA receptors with low vertebrate toxicity, our results suggest that fipronil impairs the development of spinal locomotor pathways in fish by inhibiting a structurally related glycine receptor subtype.
81(1,1,1,1) Details
17267752 Janssen D, Derst C, Buckinx R, Van den Eynden J, Rigo JM, Van Kerkhove E: Dorsal unpaired median neurons of locusta migratoria express ivermectin- and fipronil-sensitive glutamate-gated chloride channels. J Neurophysiol. 2007 Apr;97(4):2642-50. Epub 2007 Jan 31.

Together with type A GABA and strychnine-sensitive glycine receptors, glutamate-gated chloride channels (GluCl) are members of the Cys-loop family of ionotropic receptors, which mediate fast inhibitory neurotransmission.
1(0,0,0,1) Details
10698677 Kamijima M, Casida JE: Regional modification of [(3) H] Ethynylbicycloorthobenzoate binding in mouse brain GABA (A) receptor by endosulfan, fipronil, and avermectin B (1a). Toxicol Appl Pharmacol. 2000 Mar 1;163(2):188-94.

AVM increased [(3) H] EBOB binding in most regions and was the only one of the three agents inhibiting in vitro [(3) H] strychnine binding to the glycine receptor.
1(0,0,0,1) Details
7533909 Millar NS, Buckingham SD, Sattelle DB: Stable expression of a functional homo-oligomeric Drosophila GABA receptor in a Drosophila cell line. Proc Biol Sci. 1994 Dec 22;258(1353):307-14.


We have observed a reversible block of the receptor by the convulsant antagonists, picrotoxinin and EBOB, and by the insecticide fipronil.
0(0,0,0,0) Details