Protein Information

Name RRG1
Synonyms NN8 4AG; Protein NN8 4AG; RAI15; RRG 1; RRG1; Retinoic acid induced 15; Retinoic acid responsive protein; SET and MYND domain containing protein 5…

Compound Information

Name fludioxonil
CAS

Reference List

PubMed Abstract RScore(About this table)
17392518 Jones CA, Greer-Phillips SE, Borkovich KA: The response regulator RRG-1 functions upstream of a mitogen-activated protein kinase pathway impacting asexual development, female fertility, osmotic stress, and fungicide resistance in Neurospora crassa. Mol Biol Cell. 2007 Jun;18(6):2123-36. Epub 2007 Mar 28.

Similar to os mutants, Delta rrg-1 strains are sensitive to hyperosmotic conditions, and they are resistant to the fungicides fludioxonil and iprodione.
15(0,0,2,5) Details
19011080 Dongo A, Bataille-Simoneau N, Campion C, Guillemette T, Hamon B, Iacomi-Vasilescu B, Katz L, Simoneau P: The group III two-component histidine kinase of filamentous fungi is involved in the fungicidal activity of the bacterial polyketide ambruticin. Appl Environ Microbiol. 2009 Jan;75(1):127-34. Epub 2008 Nov 14.

We have shown that the plant pathogen Alternaria brassicicola exhibited very high susceptibility to ambruticin VS4 and to a lesser extent to the phenylpyrrole fungicide fludioxonil.
Parallel experiments carried out with wild-type and mutant isolates of Neurospora crassa revealed that, in this species, ambruticin susceptibility was dependent on the OS1-RRG1 branch of the phosphorelay pathway downstream of the OS2 MAPK cascade but independent of the yeast Skn7-like response regulator RRG2.
1(0,0,0,1) Details