| 19796941 |
Parlow JJ, Burney MW, Case BL, Girard TJ, Hall KA, Hiebsch RR, Huff RM, Lachance RM, Mischke DA, Rapp SR, Woerndle RS, Ennis MD: Piperazinyl-glutamate-pyrimidines as potent P2Y12 antagonists for inhibition of platelet aggregation. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6148-56. Epub 2009 Sep 10.
Piperazinyl-glutamate-pyrimidines were prepared with oxygen, nitrogen, and sulfur substitution at the 4-position of the pyrimidine leading to highly potent P2Y12 antagonists. |
32(0,1,1,2) |
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| 19464902 |
Crepaldi P, Cacciari B, Bonache MC, Spalluto G, Varani K, Borea PA, Kugelgen I, Hoffmann K, Pugliano M, Razzari C, Cattaneo M: 6-Amino-2-mercapto-3H-pyrimidin-4-one derivatives as new candidates for the antagonism at the P2Y12 receptors. Bioorg Med Chem. 2009 Jul 1;17(13):4612-21. Epub 2009 May 3.
During the last few years, our group has been working on the development of P2Y (12) receptors antagonists that are based on an extremely simple chemical structure, the 6-amino-2-mercapto-3H-pyrimidin-4-one, variously substituted at the sulfur and oxygen functions. |
1(0,0,0,1) |
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