Protein Information

Name gelatinase
Synonyms 92 kDa gelatinase; Neutrophil collagenase; 92 kDa type IV collagenase; CLG4B; Collagenase type IV B; Collagenase type V; GEL B; GELB…

Compound Information

Name sulfur
CAS sulfur

Reference List

PubMed Abstract RScore(About this table)
20227264 Rosenberger D, Gargoum R, Tyagi N, Metreveli N, Sen U, Maldonado C, Tyagi S: Homocysteine enriched diet leads to prolonged QT interval and reduced left ventricular performance in telemetric monitored mice. Nutr Metab Cardiovasc Dis. 2010 Mar 11.

BACKGROUND AND AIMS: Homocysteine (Hcy) is a sulfur-containing, non-protein amino acid produced in the metabolic pathway of methionine.
We tested the hypothesis that induction of matrix metalloproteinase-2 and matrix metalloproteinase-9 leads to connexin 40, connexin 43, connexin 45 expression changes contributing to decreased cardiac performance and disturbed atrioventricular conduction.
4(0,0,0,4) Details
19824893 Gooyit M, Lee M, Hesek D, Boggess B, Oliver AG, Fridman R, Mobashery S, Chang M: Synthesis, kinetic characterization and metabolism of diastereomeric 2-(1-(4-phenoxyphenylsulfonyl) ethyl) thiiranes as potent gelatinase and MT1-MMP inhibitors. Chem Biol Drug Des. 2009 Dec;74(6):535-46. Epub 2009 Oct 12.

Instead oxidation on the thiirane sulfur is the only biotransformation pathway observed for these gelatinase inhibitors.
36(0,1,1,6) Details
19853296 Anumolu SS, DeSantis AS, Menjoge AR, Hahn RA, Beloni JA, Gordon MK, Sinko PJ: Doxycycline loaded poly (ethylene glycol) hydrogels for healing vesicant-induced ocular wounds. Biomaterials. 2010 Feb;31(5):964-74. Epub 2009 Oct 22.

Half mustard (CEES) and nitrogen mustard (NM) are commonly used surrogates and vesicant analogs of the chemical warfare agent sulfur mustard.
Histology and immunofluorescence studies showed a significant reduction of matrix metalloproteinase-9 (MMP-9) and improved healing of vesicant-exposed corneas by doxycycline hydrogels compared to a similar dose of doxycycline delivered in phosphate buffered saline (PBS, pH 7.4).
1(0,0,0,1) Details
20148748 McDonald JD, Doyle-Eisele M, Campen MJ, Seagrave J, Holmes T, Lund A, Surratt JD, Seinfeld JH, Rohr AC, Knipping EM: Cardiopulmonary response to inhalation of biogenic secondary organic aerosol. Inhal Toxicol. 2010 Feb;22(3):253-65.


ApoE (-/-) mice were exposed for 7 days and measurements of TBARS and gene expression of heme oxygenase-1 (HO-1), endothelin-1 (ET-1), matrix metalloproteinase-9 (MMP-9) were made in aorta.
1(0,0,0,1) Details