| Name | cytochrome bc1 |
|---|---|
| Synonyms | Cytochrome bc1; D3S3191; UQCRC 1; UQCRC1; Ubiquinol cytochrome C reductase complex core protein I mitochondrial; Ubiquinol cytochrome c reductase core protein I; Ubiquinol cytochrome C reductase complex core protein I mitochondrials; Ubiquinol cytochrome c reductase core protein Is |
| Name | famoxadone |
|---|---|
| CAS | 5-methyl-5-(4-phenoxyphenyl)-3-(phenylamino)-2,4-oxazolidinedione |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10843216 | Zheng YJ, Shapiro R, Marshall WJ, Jordan DB: Synthesis and structural analysis of the active enantiomer of famoxadone, a potent inhibitor of cytochrome bc1. Bioorg Med Chem Lett. 2000 May 15;10(10):1059-62. |
162(2,2,2,2) | Details |
| 12269811 | Gao X, Wen X, Yu C, Esser L, Tsao S, Quinn B, Zhang L, Yu L, Xia D: The crystal structure of mitochondrial cytochrome bc1 in complex with famoxadone: the role of aromatic-aromatic interaction in inhibition. Biochemistry. 2002 Oct 1;41(39):11692-702. |
81(1,1,1,1) | Details |
| 10917645 | Jordan DB, Kranis KT, Picollelli MA, Schwartz RS, Sternberg JA, Sun KM: Famoxadone and oxazolidinones: potent inhibitors of cytochrome bc1. Biochem Soc Trans. 1999 Aug;27(4):577-80. |
81(1,1,1,1) | Details |
| 12525495 | Xiao K, Engstrom G, Rajagukguk S, Yu CA, Yu L, Durham B, Millett F: Effect of famoxadone on photoinduced electron transfer between the iron- center and cytochrome c1 in the cytochrome bc1 complex. J Biol Chem. 2003 Mar 28;278(13):11419-26. Epub 2003 Jan 13. |
31(0,1,1,1) | Details |
| 11561403 | Steinfeld U, Sierotzki H, Parisi S, Poirey S, Gisi U: Sensitivity of mitochondrial respiration to different inhibitors in Venturia inaequalis. Pest Manag Sci. 2001 Sep;57(9):787-96. The sensitivity of Venturia inaequalis field isolates to inhibitors of the cytochrome bc1 complex at the Qo site (QoIs) was characterised at the molecular, biochemical and physiological level, and compared to other respiration inhibitors. Cross-resistance was observed among QoIs such as trifloxystrobin, azoxystrobin, famoxadone, strobilurin B and myxothiazol. |
2(0,0,0,2) | Details |
| 17253777 | Rajagukguk S, Yang S, Yu CA, Yu L, Durham B, Millett F: Effect of mutations in the cytochrome b ef loop on the electron-transfer reactions of the Rieske iron-sulfur protein in the cytochrome bc1 complex. Biochemistry. 2007 Feb 20;46(7):1791-8. Epub 2007 Jan 25. Famoxadone binding to the Qo site decreases k1 to 5400 s-1, indicating that a conformational change on the surface of cyt b decreases the rate of release of the ISP from cyt b. |
1(0,0,0,1) | Details |
| 12767232 | Muller FL, Roberts AG, Bowman MK, Kramer DM: Architecture of the Qo site of the cytochrome bc1 complex probed by production. Biochemistry. 2003 Jun 3;42(21):6493-9. In this work, it is shown that, in addition to myxothiazol, a number of other proximal Q (o) inhibitors [including (E)-beta-methoxyacrylate-stilbene, mucidin, and famoxadone] also induce O (2)(*)(-) production in the isolated yeast cyt bc (1) complex, at approximately 50% of the V (max) observed in the presence of antimycin A. |
1(0,0,0,1) | Details |