| Name | estrogen receptors |
|---|---|
| Synonyms | ER; ERA; ER alpha; ERalpha; ESR; ESR 1; ESR1; ESRA… |
| Name | fenarimol |
|---|---|
| CAS | α-(2-chlorophenyl)-α-(4-chlorophenyl)-5-pyrimidinemethanol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15253041 | Okubo T, Yokoyama Y, Kano K, Soya Y, Kano I: Estimation of estrogenic and antiestrogenic activities of selected pesticides by MCF-7 cell proliferation assay. Arch Environ Contam Toxicol. 2004 May;46(4):445-53. Chlordecone, dicofol, methoxychlor, nitrofen, fenarimol, myclobutanil and pyridate had capacities to bind both ERalpha and AR. |
86(1,1,1,6) | Details |
| 15261991 | Grunfeld HT, Bonefeld-Jorgensen EC: Effect of in vitro estrogenic pesticides on human oestrogen receptor alpha and beta mRNA levels. Toxicol Lett. 2004 Aug 1;151(3):467-80. Like 17beta- (E2), fenarimol significantly decreased the ERalpha and increased the ERbeta mRNA level. |
11(0,0,1,6) | Details |
| 11884232 | Andersen HR, Vinggaard AM, Rasmussen TH, Gjermandsen IM, Bonefeld-Jorgensen EC: Effects of currently used pesticides in assays for estrogenicity, androgenicity, and aromatase activity in vitro. Toxicol Appl Pharmacol. 2002 Feb 15;179(1):1-12. Twenty-four pesticides were tested for interactions with the estrogen receptor (ER) and the androgen receptor (AR) in transactivation assays. Pesticides (endosulfan, methiocarb, methomyl, pirimicarb, propamocarb, deltamethrin, fenpropathrin, dimethoate, chlorpyriphos, dichlorvos, tolchlofos-methyl, vinclozolin, iprodion, fenarimol, prochloraz, fosetyl-aluminum, chlorothalonil, daminozid, paclobutrazol, chlormequat chlorid, and ethephon) were selected according to their frequent use in Danish greenhouses. |
1(0,0,0,1) | Details |
| 3672523 | Hirsch KS, Weaver DE, Black LJ, Falcone JF, MacLusky NJ: Inhibition of central nervous system aromatase activity: a mechanism for fenarimol-induced infertility in the male rat. Toxicol Appl Pharmacol. 1987 Nov;91(2):235-45. The compound did, however, prevent the increase in nuclear estrogen receptors in the brain which normally occurs in the male during the early postnatal period. |
1(0,0,0,1) | Details |
| 10789375 | Vinggaard AM, Breinholt V, Larsen JC: Screening of selected pesticides for oestrogen receptor activation in vitro. Food Addit Contam. 1999 Dec;16(12):533-42. The fungicides fenarimol, triadimefon, and triadimenol were identified as weak oestrogen receptor agonists, which at 10 microM induces a 2.0, 2.4, and 1.9-fold increase in proliferation of human MCF7 breast cancer cells (E3 clone). |
0(0,0,0,0) | Details |