Protein Information

Name nitrilase (protein family or complex)
Synonyms Nitrilase; Nitrilases

Compound Information

Name ioxynil
CAS 4-hydroxy-3,5-diiodobenzonitrile

Reference List

PubMed Abstract RScore(About this table)
17125153 Nielsen MK, Holtze MS, Svensmark B, Juhler RK: Demonstrating formation of potentially persistent transformation products from the herbicides bromoxynil and ioxynil using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Pest Manag Sci. 2007 Feb;63(2):141-9.

A similar process to the formation of BAM (2,6-dichlorobenzamide) from the herbicide dichlobenil (2,6-dichlorobenzonitrile) can be anticipated as bromoxynil and ioxynil are analogues of dichlobenil and they are degraded by the enzymes nitrilase, nitrile hydratase and amidase.
81(1,1,1,1) Details
20204468 Vesela AB, Franc M, Pelantova H, Kubac D, Vejvoda V, Sulc M, Bhalla TC, Mackova M, Lovecka P, Janu P, Demnerova K, Martinkova L: Hydrolysis of benzonitrile herbicides by soil actinobacteria and metabolite toxicity. Biodegradation. 2010 Mar 4.

None of the nitrilase-producing strains hydrolyzed dichlobenil (2,6-dichlorobenzonitrile). 3,5-Dibromo-4-hydroxybenzoic acid exhibited less inhibitory effect than bromoxynil both on luminescent bacteria and germinating seeds of Lactuca sativa. 3,5-Diiodo-4-hydroxybenzoic acid only exhibited lower toxicity than ioxynil in the latter test.
32(0,1,1,2) Details
8798929 Gabriel J, Vekova J, Vosahlo J: High-performance liquid chromatographic study of the aromatic nitrile metabolism in soil bacteria. J Chromatogr B Biomed Appl. 1996 May 31;681(1):191-5.

Simultaneous HPLC determination of bromoxynil, ioxynil and dichlobenil, three arylnitrile herbicides, and their metabolic products in soil extracts and microbiological media is described.
Assay of aromatic nitrile hydratase, amidase or nitrilase activities is possible by the method developed.
1(0,0,0,1) Details