| 19729652 |
Vanacore R, Ham AJ, Voehler M, Sanders CR, Conrads TP, Veenstra TD, Sharpless KB, Dawson PE, Hudson BG: A sulfilimine bond identified in collagen IV. Science. 2009 Sep 4;325(5945):1230-4.
The networks provide structural integrity to tissues and serve as ligands for integrin cell-surface receptors. |
1(0,0,0,1) |
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| 19546851 |
Gobbi G, Ricci F, Malinverno C, Carubbi C, Pambianco M, Panfilis G, Vitale M, Mirandola P: Hydrogen sulfide impairs keratinocyte cell growth and adhesion inhibiting mitogen-activated protein kinase signaling. Lab Invest. 2009 Sep;89(9):994-1006. Epub 2009 Jun 22.
As a mechanistic explanation of these effects, we show at the molecular level that (i) H2S reduces the Raf/MAPK kinase/ERK signaling pathway; (ii) the reduced adhesion of sulfur-treated cells is associated to the downregulation of the expression of beta4, alpha2 and alpha6 integrins that are necessary to promote cell adhesion as well as anti-apoptotic and proliferative signaling in normal keratinocytes. |
31(0,1,1,1) |
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