Protein Information

Name mitogen activated protein kinase (protein family or complex)
Synonyms MAPK; mitogen activated protein kinase; mitogen activated protein kinases

Compound Information

Name iprodione
CAS

Reference List

PubMed Abstract RScore(About this table)
17158737 Izumitsu K, Yoshimi A, Tanaka C: Two-component response regulators Ssk1p and Skn7p additively regulate high-osmolarity adaptation and fungicide sensitivity in Cochliobolus heterostrophus. Eukaryot Cell. 2007 Feb;6(2):171-81. Epub 2006 Dec 8.

We previously reported that the fungus unique group III histidine kinase regulates high-osmolarity adaptation and iprodione/fludioxonil fungicide sensitivity by controlling the phosphorylation of Hog1-type mitogen-activated protein kinase (MAPK) in filamentous ascomycetes.
82(1,1,1,2) Details
16278449 Yoshimi A, Kojima K, Takano Y, Tanaka C: Group III histidine kinase is a positive regulator of Hog1-type mitogen-activated protein kinase in filamentous fungi. Eukaryot Cell. 2005 Nov;4(11):1820-8.

In the wild-type strain, phosphorylated BmHog1p was detected after exposure to both iprodione and fludioxonil at a concentration of 1 microg/ml.
5(0,0,0,5) Details
19596074 Hagiwara D, Asano Y, Marui J, Yoshimi A, Mizuno T, Abe K: Transcriptional profiling for Aspergillusnidulans HogA MAPK signaling pathway in response to fludioxonil and osmotic stress. Fungal Genet Biol. 2009 Nov;46(11):868-78. Epub 2009 Jul 22.

In filamentous fungi, the His-Asp phosphorelay signaling system and HOG pathway are involved in the action of the fungicides, fludioxonil, and iprodione, as well as osmotic and oxidative stress responses.
From the results of microarray analyses, AtfA-dependent FUGs largely overlapped with HogA-dependent FUGs, suggesting that AtfA functions downstream of the HogA MAPK.
1(0,0,0,1) Details
12619694 Fujimura M, Ochiai N, Oshima M, Motoyama T, Ichiishi A, Usami R, Horikoshi K, Yamaguchi I: Putative homologs of SSK22 MAPKK kinase and PBS2 MAPK kinase of Saccharomyces cerevisiae encoded by os-4 and os-5 genes for osmotic sensitivity and fungicide resistance in Neurospora crassa. Biosci Biotechnol Biochem. 2003 Jan;67(1):186-91.

Disruptants of the NcSSK22 gene were sensitive to osmotic stress and resistant to iprodione and fludioxonil.
1(0,0,0,1) Details
17392518 Jones CA, Greer-Phillips SE, Borkovich KA: The response regulator RRG-1 functions upstream of a mitogen-activated protein kinase pathway impacting asexual development, female fertility, osmotic stress, and fungicide resistance in Neurospora crassa. Mol Biol Cell. 2007 Jun;18(6):2123-36. Epub 2007 Mar 28.

The cell lysis phenotype of Delta rrg-1 mutants is reminiscent of osmotic-sensitive (os) mutants, including nik-1/os-1 (a histidine kinase) and strains defective in components of a mitogen-activated protein kinase (MAPK) pathway: os-4 (MAPK kinase kinase), os-5 (MAPK kinase), and os-2 (MAPK).
Similar to os mutants, Delta rrg-1 strains are sensitive to hyperosmotic conditions, and they are resistant to the fungicides fludioxonil and iprodione.
1(0,0,0,1) Details