Protein Information

Name sodium channel (protein family or complex)
Synonyms Sodium channel

Compound Information

Name isobenzan
CAS 1,3,4,5,6,7,8,8-octachloro-1,3,3a,4,7,7a-hexahydro-4,7-methanoisobenzofuran

Reference List

PubMed Abstract RScore(About this table)
1281937 Narahashi T, Frey JM, Ginsburg KS, Roy ML: Sodium and GABA-activated channels as the targets of pyrethroids and cyclodienes. Toxicol Lett. 1992 Dec;64-65 Spec No:429-36.

The type I pyrethroid allethrin and the type II pyrethroid deltamethrin were both effective in prolonging the sodium current in the TXX-resistant sodium channel but had only a small effect on the TTX-sensitive sodium channel.
In contrast to the pyrethroids, lindane and the cyclodienes endrin, isobenzan, dieldrin and heptachlor-epoxide suppressed the GABA-induced chloride current.
1(0,0,0,1) Details